Clinical biomarkers for cancer recognition and prevention: A novel approach with optical measurements.

Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101256509 Publication Model: Print Cited Medium: Internet ISSN: 1875-8592 (Electronic) Linking ISSN: 15740153 NLM ISO Abbreviation: Cancer Biomark Subsets: MEDLINE

Original Publication: Amsterdam ; Washington, DC : IOS Press, c2005-

Biomarkers*; Neoplasms/*diagnosis ; Neoplasms/*prevention & control; Diagnostic Imaging/methods ; Genomics/methods ; Humans ; Metabolomics/methods ; Neoplasms/etiology ; Neoplasms/metabolism ; Proteomics/methods ; Sensitivity and Specificity

Cancer is the most important cause of death worldwide, and early cancer detection is the most fundamental factor for efficacy of treatment, prognosis, and increasing survival rate. Over the years great effort has been devoted to discovering and testing new biomarkers that can improve its diagnosis, especially at an early stage. Here we report the potential usefulness of new, easily applicable, non-invasive and relatively low-cost clinical biomarkers, based on abnormalities of oral mucosa spectral reflectance and fractal geometry of the vascular networks in several different tissues, for identification of hereditary non-polyposis colorectal cancer carriers as well for detection of other tumors, even at an early stage. In the near future the methodology/technology of these procedures should be improved, thus making possible their applicability worldwide as screening tools for early recognition and prevention of cancer.

Keywords: Clinical biomarkers; cancer; fractal analysis; oral mucosal network abnormalities; oral mucosal spectral reflectance

0 (Biomarkers)

Date Created: 20180426 Date Completed: 20181024 Latest Revision: 20181024

20240628

10.3233/CBM-170050

29689703