Age-related scattered hypofluorescent spots on late-phase indocyanine green angiography: the multimodal imaging and relevant factors.

Publisher: Wiley-Blackwell Pub. Asia Country of Publication: Australia NLM ID: 100896531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1442-9071 (Electronic) Linking ISSN: 14426404 NLM ISO Abbreviation: Clin Exp Ophthalmol

Publication: Carlton, Vic. : Wiley-Blackwell Pub. Asia
Original Publication: Carlton, Vic. : Blackwell Science Asia, c2000-

Multimodal Imaging*; Aging/*pathology ; Choroid/*pathology ; Choroidal Neovascularization/*diagnosis ; Fluorescein Angiography/*methods ; Tomography, Optical Coherence/*methods; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Fovea Centralis/diagnostic imaging ; Fundus Oculi ; Humans ; Male ; Middle Aged ; Reference Values ; Retrospective Studies ; Young Adult

Importance: Fundus aging and its imaging features.
Background: To characterize the demographic and multimodal-imaging features of age-related scattered hypofluorescent spots on late-phase indocyanine green angiography (ASHS-LIA).
Design: A hospital-based retrospective study.
Participants: Eight hundred and seventy-five normal fundi fellow eyes from 875 patients underwent indocyanine green angiography (ICGA), fluorescence angiography (FA), autofluorescence (AF) and spectral-domain optical coherence tomography (OCT).
Methods: Demographic information, medical records and multimodal imaging data were reviewed.
Main Outcome Measures: Diameter of ASHS-LIA and its grade, subfoveal choroidal thickness (SFCT).
Results: ASHS-LIA was identified in 233 patients (26.6%) aged 33 to 87 years (mean: 65.8 ± 8.4 years). Patients with ASHS-LIA were significantly older and had a higher male proportion than those without ASHS-LIA (both P < 0.001). The occurrence and grade of ASHS-LIA increased with age (all P < 0.001). Age (OR = 1.093) and male gender (OR = 1.550) were the independent relevant factors of ASHS-LIA (P < 0.001, and P = 0.002, respectively). The incidence of ASHS-LIA in polypoidal choroidal vasculopathy (PCV) patients (53.2%) was the highest (all P < 0.001). ASHS-LIA mainly located in macular region (diameter: 100-500 μm), and could be confluent. No corresponding abnormalities were detected via multimodal imaging, including FA, AF and OCT. The mean SFCT had no significant difference between eyes with and without ASHS-LIA (P = 0.221).
Conclusions and Relevance: ASHS-LIA was observed on late-phase ICGA, mainly located in macular region. No corresponding abnormalities were detected by other multimodal imaging, including FA, AF and OCT. The occurrence and grade of ASHS-LIA increased with age. Moreover, ASHS-LIA might be not correlated with SFCT, but correlated with PCV.
(© 2018 The Authors Clinical & Experimental Ophthalmology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Ophthalmologists.)

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Keywords: age-related hypofluorescent spots; fundus aging; indocyanine green angiography; multimodal imaging; polypoidal choroidal vasculopathy

Date Created: 20180421 Date Completed: 20190820 Latest Revision: 20190820

20221213

PMC6282543

10.1111/ceo.13306

29675907