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Up-regulated Cx43 phosphorylation at Ser368 prolongs QRS duration in myocarditis.

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE
    • بيانات النشر:
      Publication: Oxford, England : Wiley-Blackwell
      Original Publication: Bucharest : "Carol Davila" University Press, 2000-
    • الموضوع:
      Electrocardiography*; Connexin 43/*metabolism ; Myocarditis/*metabolism ; Myocarditis/*physiopathology; Animals ; Cell Communication ; Disease Models, Animal ; Heart/physiopathology ; Interleukin-1beta/metabolism ; MAP Kinase Signaling System ; Male ; Myocardium/cytology ; Myocardium/metabolism ; Organ Culture Techniques ; Phosphorylation ; Rats, Inbred Lew ; Serine/metabolism ; Up-Regulation
    • نبذة مختصرة :
      Prolongation of QRS duration in electrocardiogram is one of the risk factors for morbidity and mortality in many kinds of cardiac diseases. However, its molecular mechanism is unknown. In this study, utilizing experimental autoimmune myocarditis (EAM) as a disease model, we show that the prolongation of QRS duration is accompanied by elevated phosphorylation of connexin 43 (Cx43) at Ser368 (p S 368 Cx43). In cultured cells, inflammatory cytokine IL-1β activates p38 MAPK to up-regulate p S 368 Cx43 and impairs cell-to-cell communication. In isolated hearts of normal rats, perfusion of IL-1β not only increases p S 368 Cx43 but also impairs cell-to-cell communication and prolongs QRS duration. Furthermore, blockade of p38 MAPK down-regulates p S 368 Cx43, improves cell-to-cell communication and reduces QRS duration in EAM. These findings suggest that up-regulation of p S 368 Cx43 by IL-1β via p38 MAPK contributes to the prolongation of QRS duration and could be a therapeutic target for myocarditis-induced prolongation of QRS duration.
      (© 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.)
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    • Contributed Indexing:
      Keywords: IL-1β; QRS duration; connexin 43; experimental autoimmune myocarditis; p38 MAPK
    • الرقم المعرف:
      0 (Connexin 43)
      0 (Gja1 protein, rat)
      0 (IL1B protein, rat)
      0 (Interleukin-1beta)
      452VLY9402 (Serine)
    • الموضوع:
      Date Created: 20180418 Date Completed: 20191213 Latest Revision: 20210109
    • الموضوع:
      20231215
    • الرقم المعرف:
      PMC6010859
    • الرقم المعرف:
      10.1111/jcmm.13631
    • الرقم المعرف:
      29664174