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Pilot Study of the Effects of Ambient Light Level Variation on Spectral Domain Anterior Segment OCT-Derived Angle Metrics in Caucasians versus Asians.

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  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 8104312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2202 (Electronic) Linking ISSN: 02713683 NLM ISO Abbreviation: Curr Eye Res Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: London : IRL Press, [c1981-
    • الموضوع:
      Asian People* ; White People*; Anterior Eye Segment/*diagnostic imaging ; Glaucoma/*physiopathology ; Tomography, Optical Coherence/*methods; Adult ; Anterior Eye Segment/physiopathology ; Female ; Glaucoma/diagnosis ; Glaucoma/ethnology ; Healthy Volunteers ; Humans ; Incidence ; Lighting ; Male ; Ophthalmoscopy ; Pilot Projects ; United States/epidemiology
    • نبذة مختصرة :
      Purpose: To investigate the effects of ambient light level variation on spectral domain anterior segment optical coherence tomography (SD-ΟCT)-derived anterior chamber angle metrics in Caucasians versus Asians.
      Materials and Methods: Caucasian (n = 24) and Asian participants of Chinese ancestry (n = 24) with open angles on gonioscopy had one eye imaged twice at five strictly controlled, ambient light levels. Ethnicity was self-reported. Light levels were strictly controlled using a light meter at 1.0, 0.75, 0.5, 0.25, and 0 foot candle illumination levels. SD-OCT 5-line raster scans at the inferior 270° irido-corneal angle were measured by two trained, masked graders from the Doheny Image Reading Center using customized Image-J software. Schwalbe's line-angle opening distance (SL-AOD) and SL-trabecular iris space area (SL-TISA) in different light meter readings (LMRs) between the two groups were compared.
      Results: Baseline light SL-AOD and SL-TISA measured 0.464 ± 0.115mm/0.351 ± 0.110mm 2 and 0.344 ± 0.118mm/0.257 ± 0.092mm 2 , respectively, in the Caucasian and the Asian group. SL-AOD and SL-TISA in each LMR were significantly larger in the Caucasian group compared to the Asian group (p < 0.05). Despite this difference in angle size between the groups, there were no statistically significant differences in the degree of change in angle parameters from light to dark (% changes in SL-AOD or SL-TISA between the two groups were statistically similar with all p-values >0.3).
      Conclusion: SL-based angle dimensions using SD-OCT are sensitive to changes in ambient illumination in participants with Caucasian and Asian ancestry. Although Caucasian eyes had larger baseline angle opening under bright light conditions, the light-to-dark change in angle dimensions was similar in the two groups.
    • Contributed Indexing:
      Keywords: Anterior chamber angle; anterior-segment OCT; glaucoma; imaging; optical coherence tomography
    • الموضوع:
      Date Created: 20180412 Date Completed: 20190521 Latest Revision: 20221207
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1080/02713683.2018.1464192
    • الرقم المعرف:
      29641953