Local transformations of the hippocampal cognitive map.

Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-

Brain Mapping* ; Cognition*; Hippocampus/*cytology ; Hippocampus/*physiology; Animals ; Male ; Rats ; Rats, Inbred Strains

Grid cells are neurons active in multiple fields arranged in a hexagonal lattice and are thought to represent the "universal metric for space." However, they become nonhomogeneously distorted in polarized enclosures, which challenges this view. We found that local changes to the configuration of the enclosure induce individual grid fields to shift in a manner inversely related to their distance from the reconfigured boundary. The grid remained primarily anchored to the unchanged stable walls and showed a nonuniform rescaling. Shifts in simultaneously recorded colocalized grid fields were strongly correlated, which suggests that the readout of the animal's position might still be intact. Similar field shifts were also observed in place and boundary cells-albeit of greater magnitude and more pronounced closer to the reconfigured boundary-which suggests that there is no simple one-to-one relationship between these three different cell types.
(Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)

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United Kingdom WT_ Wellcome Trust; 203020/Z/16/Z United Kingdom WT_ Wellcome Trust; 206682/Z/17/Z United Kingdom WT_ Wellcome Trust; R21 AT003212 United States AT NCCIH NIH HHS

Date Created: 20180329 Date Completed: 20180504 Latest Revision: 20240610

20240610

PMC6331044

10.1126/science.aao4960

29590044