Prevalence of Low Birth Weight before and after Policy Change to IPTp-SP in Two Selected Hospitals in Southern Nigeria: Eleven-Year Retrospective Analyses.

Publisher: Wiley Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE

Publication: 2024- : [Hoboken, NJ] : Wiley
Original Publication: New York, NY : Hindawi Pub. Co.

Infant, Low Birth Weight*; Gravidity/*physiology ; Malaria, Falciparum/*drug therapy ; Pregnancy Complications/*physiopathology; Adult ; Drug Combinations ; Female ; Humans ; Infant, Newborn ; Malaria, Falciparum/complications ; Malaria, Falciparum/parasitology ; Malaria, Falciparum/physiopathology ; Nigeria/epidemiology ; Plasmodium falciparum/pathogenicity ; Pregnancy ; Pregnancy Complications/chemically induced ; Pregnancy Complications/epidemiology ; Pyrimethamine/adverse effects ; Sulfadoxine/adverse effects

Background: In 2005, Nigeria changed its policy on prevention of malaria in pregnancy to intermittent preventive treatment with sulphadoxine-pyrimethamine (IPTp-SP). Indicators of impact of effective prevention and control of malaria on pregnancy (MIP) are low birth weight (LBW) and maternal anaemia by parity. This study determined the prevalence of LBW for different gravidity groups during periods of pre- and postpolicy change to IPTp-SP.
Methods: Eleven-year data were abstracted from the delivery registers of two hospitals. Study outcomes calculated for both pre- (2000-2004) and post-IPTp-SP-policy (2005-2010) years were prevalence of LBW for different gravidity groups and risk of LBW in primigravidae compared to multigravidae.
Results: Out of the 11,496 singleton deliveries recorded within the 11-year period, the prevalence of LBW was significantly higher in primigravidae than in multigravidae for both prepolicy (6.3% versus 4%) and postpolicy (8.6% versus 5.1%) years. The risk of LBW in primigravidae compared to multigravidae increased from 1.62 (1.17-2.23) in the prepolicy years to 1.74 (1.436-2.13) during the postpolicy years.
Conclusion: The study demonstrated that both the prevalence and risk of LBW remained significantly higher in primigravidae even after the change in policy to IPTp-SP.

Trans R Soc Trop Med Hyg. 1983;77(2):232-44. (PMID: 6346592)
Clin Microbiol Rev. 2004 Oct;17(4):760-9, table of contents. (PMID: 15489346)
BJOG. 2011 May;118(6):671-8. (PMID: 21332632)
Malar J. 2007 Dec 04;6:160. (PMID: 18053209)
Ann Trop Med Parasitol. 1999 Mar;93(2):119-33. (PMID: 10474637)
Niger J Clin Pract. 2011 Oct-Dec;14(4):418-21. (PMID: 22248941)
Malar J. 2007 Jul 06;6:88. (PMID: 17617910)
Br Med Bull. 2003;67:137-48. (PMID: 14711760)
Drug Saf. 2007;30(6):481-501. (PMID: 17536875)
Int J Epidemiol. 1991 Mar;20(1):276-83. (PMID: 2066235)
Ann Trop Med Parasitol. 1999 Dec;93 Suppl 1:S43-57. (PMID: 10715688)
J Pregnancy. 2011;2011:481095. (PMID: 21547090)
Cochrane Database Syst Rev. 2003;(1):CD000169. (PMID: 12535391)

0 (Drug Combinations)
37338-39-9 (fanasil, pyrimethamine drug combination)
88463U4SM5 (Sulfadoxine)
Z3614QOX8W (Pyrimethamine)

Date Created: 20180308 Date Completed: 20180822 Latest Revision: 20220316

20250114

PMC5817332

10.1155/2018/4658106

29511681