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Fibrous nanocellulose, crystalline nanocellulose, carbon nanotubes, and crocidolite asbestos elicit disparate immune responses upon pharyngeal aspiration in mice.
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- معلومة اضافية
- المصدر:
Publisher: Informa Healthcare Country of Publication: England NLM ID: 101201960 Publication Model: Print Cited Medium: Internet ISSN: 1547-6901 (Electronic) Linking ISSN: 1547691X NLM ISO Abbreviation: J Immunotoxicol Subsets: MEDLINE
- بيانات النشر:
Publication: London : Informa Healthcare
Original Publication: Philadelphia, PA : Taylor & Francis Health Sciences, c2004-
- الموضوع:
- نبذة مختصرة :
With the rapid development of synthetic alternatives to mineral fibers, their possible effects on the environment and human health have become recognized as important issues worldwide. This study investigated effects of four fibrous materials, i.e. nanofibrillar/nanocrystalline celluloses (NCF and CNC), single-walled carbon nanotubes (CNTs), and crocidolite asbestos (ASB), on pulmonary inflammation and immune responses found in the lungs, as well as the effects on spleen and peripheral blood immune cell subsets. BALB/c mice were given NCF, CNC, CNT, and ASB on Day 1 by oropharyngeal aspiration. At 14 days post-exposure, the animals were evaluated. Total cell number, mononuclear phagocytes, polymorphonuclear leukocytes, lymphocytes, and LDH levels were significantly increased in ASB and CNT-exposed mice. Expression of cytokines and chemokines in bronchoalveolar lavage (BAL) was quite different in mice exposed to four particle types, as well as expression of antigen presentation-related surface proteins on BAL cells. The results revealed that pulmonary exposure to fibrous materials led to discrete local immune cell polarization patterns with a T H 2-like response caused by ASB and T H 1-like immune reaction to NCF, while CNT and CNC caused non-classical or non-uniform responses. These alterations in immune response following pulmonary exposure should be taken into account when testing the applicability of new nanosized materials with fibrous morphology.
- Contributed Indexing:
Keywords: Nanocellulose; antigen-presenting cells; carbon nanotubes; crocidolite asbestos; immune response; pulmonary exposure
- الرقم المعرف:
0 (Cytokines)
0 (Mineral Fibers)
0 (Nanotubes, Carbon)
12001-28-4 (Asbestos, Crocidolite)
9004-34-6 (Cellulose)
OP1R32D61U (microcrystalline cellulose)
- الموضوع:
Date Created: 20171215 Date Completed: 20180808 Latest Revision: 20180828
- الموضوع:
20231215
- الرقم المعرف:
10.1080/1547691X.2017.1414339
- الرقم المعرف:
29237319
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