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Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Malden, MA : WileyBlackwell Pub., 2008-
    • الموضوع:
      Evidence-Based Medicine/*methods ; Health Plan Implementation/*statistics & numerical data ; National Health Programs/*statistics & numerical data ; Pharmacogenomic Testing/*statistics & numerical data ; Precision Medicine/*methods; Evidence-Based Medicine/trends ; Feasibility Studies ; Genotype ; Health Plan Implementation/trends ; Humans ; National Health Programs/trends ; Oligonucleotide Array Sequence Analysis/statistics & numerical data ; Oligonucleotide Array Sequence Analysis/trends ; Pharmacogenomic Testing/trends ; Polymorphism, Single Nucleotide/genetics ; Precision Medicine/trends ; Spain
    • نبذة مختصرة :
      In 2014, we established a pharmacogenetics unit with the intention of facilitating the integration of pharmacogenetic testing into clinical practice. This unit was centered around two main ideas: i) individualization of clinical recommendations, and ii) preemptive genotyping in risk populations. Our unit is based on the design and validation of a single nucleotide polymorphism (SNP) microarray, which has allowed testing of 180 SNPs associated with drug response (PharmArray), and clinical consultation regarding the results. Herein, we report our experience in integrating pharmacogenetic testing into our hospital and we present the results of the 2,539 pharmacogenetic consultation requests received over the past 3 years in our unit. The results demonstrate the feasibility of implementing pharmacogenetic testing in clinical practice within a national health system.
      (© 2017 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.)
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    • Contributed Indexing:
      Keywords: individualization; pharmacogenetics; precision medicine
    • الموضوع:
      Date Created: 20171202 Date Completed: 20190405 Latest Revision: 20241105
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC5866958
    • الرقم المعرف:
      10.1111/cts.12526
    • الرقم المعرف:
      29193749