New cytotoxic sesquiterpene lactones from Achillea cretica L. growing in Tunisia.

Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2213 (Electronic) Linking ISSN: 10286020 NLM ISO Abbreviation: J Asian Nat Prod Res Subsets: MEDLINE

Publication: London : Informa Healthcare
Original Publication: [Newark, N.J.?] : Harwood Academic Publishers,

Achillea/*chemistry ; Antineoplastic Agents, Phytogenic/*isolation & purification ; Antineoplastic Agents, Phytogenic/*pharmacology ; Lactones/*isolation & purification ; Lactones/*pharmacology ; Sesquiterpenes, Guaiane/*isolation & purification ; Sesquiterpenes, Guaiane/*pharmacology; Antineoplastic Agents, Phytogenic/chemistry ; Drug Screening Assays, Antitumor ; HCT116 Cells ; Humans ; Lactones/chemistry ; Molecular Structure ; Sesquiterpenes, Guaiane/chemistry ; Tunisia

The phytochemical study of Achillea cretica growing in Tunisia led to the isolation of two novel sesquiterpene lactones, which have been designated achicretin 1 and achicretin 2. Their chemical structures were further confirmed by mass spectroscopy (ESI-MS) and by extensive application of one- and two-dimensional NMR spectroscopy. The isolated compounds were tested for their cytotoxic activity against four human cancer cell lines, IGROV-1, OVCAR-3, MCF-7, and HCT-116 using the MTT assay. It has been found that achicretin 2 exhibited more potent inhibitory activity with IC 50  = values of 14.0 ± 1.0 and 16.0 ± 2.0 μM against OVCAR-3 and HCT-116 cells, respectively.

Keywords: Achillea cretica; cytotoxic activity; guaianolide; sesquiterpenes

0 (Antineoplastic Agents, Phytogenic)
0 (Lactones)
0 (Sesquiterpenes, Guaiane)

Date Created: 20171122 Date Completed: 20180509 Latest Revision: 20180509

20240829

10.1080/10286020.2017.1355362

29160111