Safety of folic acid.

Publisher: New York Academy of Sciences Country of Publication: United States NLM ID: 7506858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1749-6632 (Electronic) Linking ISSN: 00778923 NLM ISO Abbreviation: Ann N Y Acad Sci

Publication: 2006- : New York, NY : Malden, MA : New York Academy of Sciences ; Blackwell
Original Publication: New York, The Academy.

Folic Acid/*administration & dosage ; Folic Acid/*adverse effects ; Neural Tube Defects/*prevention & control; Animals ; Cognitive Dysfunction/etiology ; Diabetes Mellitus/etiology ; Dietary Supplements ; Female ; Food, Fortified ; Humans ; Hypersensitivity/etiology ; Infant, Newborn ; Male ; Maximum Tolerated Dose ; Neoplasms/etiology ; No-Observed-Adverse-Effect Level ; Pregnancy ; Risk Factors ; Safety ; Thyroid Diseases/etiology ; United States ; United States Food and Drug Administration

There is a large body of literature demonstrating the efficacy of maternal folic acid intake in preventing birth defects, as well as investigations into potential adverse consequences of consuming folic acid above the upper intake level (UL). Recently, two authoritative bodies convened expert panels to assess risks from high intakes of folic acid: the U.S. National Toxicology Program and the UK Scientific Advisory Committee on Nutrition. Overall, the totality of the evidence examined by these panels, as well as studies published since the release of their reports, have not established risks for adverse consequences resulting from existing mandatory folic acid fortification programs that have been implemented in many countries. Current folic acid fortification programs have been shown to support public health in populations, and the exposure levels are informed by and adherent to the precautionary principle. Additional research is needed to assess the health effects of folic acid supplement use when the current upper limit for folic acid is exceeded.
(© 2017 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals, Inc. on behalf of New York Academy of Sciences.)

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R01 HD059120 United States HD NICHD NIH HHS; R37 DK058144 United States DK NIDDK NIH HHS

Keywords: cancer; folate; folic acid; neural tube defects; safety

935E97BOY8 (Folic Acid)

Date Created: 20171121 Date Completed: 20190730 Latest Revision: 20240323

20240323

PMC5849489

10.1111/nyas.13499

29155442