The influences of walking, running and stair activity on knee articular cartilage: Quantitative MRI using T1 rho and T2 mapping.

Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Original Publication: San Francisco, CA : Public Library of Science

Running* ; Walking*; Cartilage, Articular/*physiology ; Knee Joint/*physiology ; Magnetic Resonance Imaging/*methods; Adult ; Cartilage, Articular/diagnostic imaging ; Female ; Humans ; Knee Joint/diagnostic imaging ; Male ; Young Adult

Objective: To explore the different influences of walking, running and stair activity on knee articular cartilage with T1 rho and T2 mapping sequences.
Materials and Methods: MRI (3.0-T) scans of the right knee were performed in twenty-three young healthy adults immediately after 30 minutes of rest, walking, running and stair activity respectively. Articular cartilage was quantitatively assessed based on T1 rho and T2 relaxation times. Analysis of variance for random block design data, bonferroni test and paired samples t tests were performed to estimate the different influences of physiological activities on articular cartilage.
Results: T1 rho and T2 values had reductions after physiological activities in all regions of articular cartilage. T1 rho and T2 values were decreased more after running than walking. T1 rho and T2 values were decreased more after stair activity than running, except for femoral cartilage. The superficial layer of patella cartilage had higher reduction rates than the deep layer. The T1 rho and T2 values of articular cartilage were reduced in the following order: patellofemoral cartilage> medial tibiofemoral cartilage> lateral tibiofemoral cartilage. Patellofemoral cartilage experienced reductions in the following order: lateral part> middle part> medial part. Tibiofemoral cartilage had reductions in the following order: posterior part> middle part> anterior part.
Conclusions: T1 rho and T2 mapping sequences can quantitatively reflect the different influences of physiological activities on knee articular cartilage. Fluid shifts, collagen fiber deformation, spatial heterogeneity, inherent differences in material properties and tissue stiffness have close relationship with cartilage loading characteristics.

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Date Created: 20171115 Date Completed: 20171226 Latest Revision: 20181113

20240628

PMC5685565

10.1371/journal.pone.0187008

29136015