Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Intestinal anti-transglutaminase 2 immunoglobulin A deposits in children at risk for coeliac disease (CD): data from the PreventCD study.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 0057202 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2249 (Electronic) Linking ISSN: 00099104 NLM ISO Abbreviation: Clin Exp Immunol Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2022- : Oxford : Oxford University Press
      Original Publication: Oxford : Blackwell Scientific Publications
    • الموضوع:
      Antigen-Antibody Complex/*metabolism ; Autoantibodies/*metabolism ; Celiac Disease/*immunology ; GTP-Binding Proteins/*immunology ; Immunoglobulin A/*metabolism ; Intestinal Mucosa/*immunology ; Transglutaminases/*immunology; Atrophy ; Biopsy ; Celiac Disease/diagnosis ; Child ; Child, Preschool ; Disease Progression ; Europe ; Female ; Humans ; Infant ; Intestinal Mucosa/pathology ; Male ; Prognosis ; Protein Glutamine gamma Glutamyltransferase 2 ; Risk Factors
    • نبذة مختصرة :
      In coeliac disease (CD), anti-tissue transglutaminase 2 immunoglobulin (Ig)A antibodies (anti-TG2) are produced and deposited in the intestine. PreventCD (www.preventcd.com) is a European multi-centre study, which investigates the influence of infant nutrition and that of genetic, immunological and other environmental factors on the risk of developing CD. The aim of the current study was to evaluate the appearance of intestinal anti-TG2 deposits in very early intestinal biopsies from at-risk infants and their predictive value for villous atrophy. Sixty-five small bowel biopsies, performed in 62 children, were investigated for the presence of intestinal anti-TG2 extracellular IgA deposits by using double immunofluorescence. The biopsies were performed in the presence of elevated serum levels of CD-associated antibodies and/or symptoms suggesting disease. Deposits of anti-TG2 IgA were present in 53 of 53 CD patients and three of three potential CD patients. In potential CD patients, mucosal deposits showed a patchy distribution characterized by some areas completely negative, whereas active CD patients had uniformly present and evident mucosal deposits. Only one of six patients without CD (negative for serum anti-TG2 and with normal mucosa) had intestinal deposits with a patchy distribution and a weak staining. Two of the 53 CD patients received a definitive diagnosis of CD after a second or third biopsy; mucosal deposits of anti-TG2 IgA were evaluated in all samples. Before developing villous atrophy, both patients had anti-TG2 deposits in normal mucosal architecture, antibodies in one patient being absent in serum. We demonstrated that in CD the intestinal deposits of anti-TG2 are a constant presence and appear very early in the natural history of disease.
      (© 2017 British Society for Immunology.)
    • References:
      Am J Gastroenterol. 2014 Jun;109(6):913-21. (PMID: 24777149)
      Clin Exp Immunol. 2013 Jan;171(1):69-75. (PMID: 23199325)
      J Clin Gastroenterol. 2010 Aug;44(7):483-8. (PMID: 19779364)
      Nat Med. 1997 Jul;3(7):797-801. (PMID: 9212111)
      N Engl J Med. 2014 Oct 2;371(14):1304-15. (PMID: 25271603)
      Arch Dis Child. 1990 Aug;65(8):909-11. (PMID: 2205160)
      Eur J Gastroenterol Hepatol. 1999 Oct;11(10):1185-94. (PMID: 10524652)
      Gut. 2006 Dec;55(12):1746-53. (PMID: 16571636)
      J Pediatr Gastroenterol Nutr. 2012 Feb;54(2):229-41. (PMID: 22266486)
      Aliment Pharmacol Ther. 2006 Aug 1;24(3):541-52. (PMID: 16886921)
      J Pediatr Gastroenterol Nutr. 2008 Sep;47(3):293-8. (PMID: 18728524)
      J Immunol. 2001 Mar 15;166(6):4170-6. (PMID: 11238668)
      Gut. 2004 May;53(5):641-8. (PMID: 15082580)
      Clin Gastroenterol Hepatol. 2011 Apr;9(4):320-5; quiz e36. (PMID: 20851213)
      J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):136-60. (PMID: 22197856)
      Scand J Gastroenterol. 2005 May;40(5):564-72. (PMID: 16036509)
      Dig Liver Dis. 2011 Aug;43(8):604-8. (PMID: 21342796)
    • Contributed Indexing:
      Keywords: PreventCD; coeliac disease; intestinal anti-TG2 antibodies; intestinal deposits
    • الرقم المعرف:
      0 (Antigen-Antibody Complex)
      0 (Autoantibodies)
      0 (Immunoglobulin A)
      0 (TGM2 protein, human)
      EC 2.3.2.13 (Protein Glutamine gamma Glutamyltransferase 2)
      EC 2.3.2.13 (Transglutaminases)
      EC 3.6.1.- (GTP-Binding Proteins)
    • الموضوع:
      Date Created: 20171109 Date Completed: 20190204 Latest Revision: 20211204
    • الموضوع:
      20221213
    • الرقم المعرف:
      PMC5801494
    • الرقم المعرف:
      10.1111/cei.13078
    • الرقم المعرف:
      29114847