The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design.

Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101541838 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-9307 (Electronic) Linking ISSN: 18789293 NLM ISO Abbreviation: Dev Cogn Neurosci Subsets: MEDLINE

Original Publication: Amsterdam : Elsevier

Adolescent Development/*physiology ; Brain/*growth & development ; Cognition/*physiology ; Cognitive Neuroscience/*methods ; Twins, Monozygotic/*genetics; Adolescent ; Child ; Female ; Humans ; Male ; Research Design

The ABCD twin study will elucidate the genetic and environmental contributions to a wide range of mental and physical health outcomes in children, including substance use, brain and behavioral development, and their interrelationship. Comparisons within and between monozygotic and dizygotic twin pairs, further powered by multiple assessments, provide information about genetic and environmental contributions to developmental associations, and enable stronger tests of causal hypotheses, than do comparisons involving unrelated children. Thus a sub-study of 800 pairs of same-sex twins was embedded within the overall Adolescent Brain and Cognitive Development (ABCD) design. The ABCD Twin Hub comprises four leading centers for twin research in Minnesota, Colorado, Virginia, and Missouri. Each site is enrolling 200 twin pairs, as well as singletons. The twins are recruited from registries of all twin births in each State during 2006-2008. Singletons at each site are recruited following the same school-based procedures as the rest of the ABCD study. This paper describes the background and rationale for the ABCD twin study, the ascertainment of twin pairs and implementation strategy at each site, and the details of the proposed analytic strategies to quantify genetic and environmental influences and test hypotheses critical to the aims of the ABCD study.
(Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.)

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U24 DA041147 United States DA NIDA NIH HHS; U01 DA051018 United States DA NIDA NIH HHS; U01 DA041093 United States DA NIDA NIH HHS; U24 DA041123 United States DA NIDA NIH HHS; U01 DA051038 United States DA NIDA NIH HHS; U01 DA041022 United States DA NIDA NIH HHS; U01 DA041089 United States DA NIDA NIH HHS; U01 DA041106 United States DA NIDA NIH HHS; U01 DA041048 United States DA NIDA NIH HHS; U01 DA041148 United States DA NIDA NIH HHS; U01 DA041174 United States DA NIDA NIH HHS; P50 HD027802 United States HD NICHD NIH HHS; U01 DA041120 United States DA NIDA NIH HHS

Keywords: Brain function; Brain structure; Environment; Heritability; Substance use; Twins

Date Created: 20171107 Date Completed: 20180912 Latest Revision: 20230131

20231215

PMC5847422

10.1016/j.dcn.2017.09.001

29107609