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Uncovering protein-protein interactions through a team-based undergraduate biochemistry course.

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  • معلومة اضافية
    • المصدر:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: San Francisco, CA : Public Library of Science, [2003]-
    • الموضوع:
      Curriculum* ; Protein Interaction Maps* ; Teaching*; Biochemistry/*education ; Research/*education; Cytochrome P-450 Enzyme System/metabolism ; Humans ; Laboratories/standards ; Learning ; Mixed Function Oxygenases/metabolism ; Students
    • نبذة مختصرة :
      How can we provide fertile ground for students to simultaneously explore a breadth of foundational knowledge, develop cross-disciplinary problem-solving skills, gain resiliency, and learn to work as a member of a team? One way is to integrate original research in the context of an undergraduate biochemistry course. In this Community Page, we discuss the development and execution of an interdisciplinary and cross-departmental undergraduate biochemistry laboratory course. We present a template for how a similar course can be replicated at other institutions and provide pedagogical and research results from a sample module in which we challenged our students to study the binding interface between 2 important biosynthetic proteins. Finally, we address the community and invite others to join us in making a larger impact on undergraduate education and the field of biochemistry by coordinating efforts to integrate research and teaching across campuses.
    • References:
      Anal Biochem. 2016 Feb 15;495 :42-51. (PMID: 26655390)
      Angew Chem Int Ed Engl. 2014 Aug 4;53(32):8518-22. (PMID: 25044735)
      PLoS Biol. 2011 Nov;9(11):e1001174. (PMID: 22110400)
      ACS Chem Biol. 2013 Nov 15;8(11):2586-96. (PMID: 24079328)
      Biochem Mol Biol Educ. 2017 Jan 2;45(1):7-12. (PMID: 27357379)
    • Grant Information:
      R15 GM120704 United States GM NIGMS NIH HHS
    • الرقم المعرف:
      9035-51-2 (Cytochrome P-450 Enzyme System)
      EC 1.- (Mixed Function Oxygenases)
      EC 1.14.13.50 (pentachlorophenol monooxygenase)
    • الموضوع:
      Date Created: 20171102 Date Completed: 20171218 Latest Revision: 20181113
    • الموضوع:
      20231215
    • الرقم المعرف:
      PMC5683658
    • الرقم المعرف:
      10.1371/journal.pbio.2003145
    • الرقم المعرف:
      29091712