Intervertebral disc degeneration: an experimental and numerical study using a rabbit model.

Publisher: Springer Country of Publication: United States NLM ID: 7704869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1741-0444 (Electronic) Linking ISSN: 01400118 NLM ISO Abbreviation: Med Biol Eng Comput Subsets: MEDLINE

Publication: New York, NY : Springer
Original Publication: Stevenage, Eng., Peregrinus.

Numerical Analysis, Computer-Assisted*; Intervertebral Disc Degeneration/*pathology; Animals ; Biomechanical Phenomena ; Compressive Strength ; Computer Simulation ; Disease Models, Animal ; Female ; Finite Element Analysis ; Intervertebral Disc Degeneration/physiopathology ; Magnetic Resonance Imaging ; Rabbits ; Reproducibility of Results

Animal models have been extensively used for the study of degenerative diseases and evaluation of new therapies to stop or even reverse the disease progression. The aim of this study is to reproduce lumbar intervertebral disc degeneration in a rabbit model by performing a percutaneous annular puncture at L4L5 level. The effect of this damage on the spine behaviour was analysed combining three different techniques: imaging processing, mechanical testing and computational modelling. Twenty New Zealand white rabbits were divided into control and experimental groups and followed up during 6 months. Intervertebral disc height, as well as nucleus area and signal intensity, decreased with degeneration while storage and loss moduli increased. Both changes may be related to the loss of water and tissue fibrosis. Similar but slighter changes were reported for adjacent discs. A finite element model was built based on MRI and mechanical testing findings to add new biomechanical information that cannot be obtained experimentally. Four stages were computationally simulated representing the different experimental phases. The numerical simulations showed that compressive stresses in the damaged and adjacent discs were modified with the progression of degeneration. Although extrapolation to humans should be carefully made, the use of numerical animal models combined with an experimental one could give a new insight of the overall mechanical behaviour of the spine.

J Biomech. 2013 Jun 21;46(10):1714-21. (PMID: 23643028)
Best Pract Res Clin Rheumatol. 2010 Apr;24(2):155-65. (PMID: 20227638)
Biomech Model Mechanobiol. 2017 Apr;16(2):537-547. (PMID: 27664020)
Spine (Phila Pa 1976). 1990 Aug;15(8):762-7. (PMID: 2237626)
Comput Methods Biomech Biomed Engin. 2011 Aug;14(8):729-39. (PMID: 21390934)
Spine (Phila Pa 1976). 2008 Mar 15;33(6):E166-73. (PMID: 18344845)
Eur Spine J. 2008 Jan;17(1):2-19. (PMID: 17632738)
World Neurosurg. 2015 Aug;84(2):438-45. (PMID: 25886720)
Spine (Phila Pa 1976). 1996 May 15;21(10):1174-84. (PMID: 8727192)
Clin Biomech (Bristol, Avon). 2017 Jul;46:6-14. (PMID: 28463696)
Spine (Phila Pa 1976). 1996 Sep 1;21(17):1945-51. (PMID: 8883192)
Spine (Phila Pa 1976). 1990 May;15(5):411-5. (PMID: 2363069)
J Spinal Disord. 1992 Jun;5(2):170-4. (PMID: 1606375)
J Orthop Res. 1994 Jan;12(1):93-102. (PMID: 8113947)
Spine (Phila Pa 1976). 2005 Jan 1;30(1):33-7. (PMID: 15626978)
Spine (Phila Pa 1976). 2005 Jan 1;30(1):15-24. (PMID: 15626975)
Spine (Phila Pa 1976). 2003 Oct 15;28(20):2338-45. (PMID: 14560080)
Spine J. 2005 Nov-Dec;5(6 Suppl):267S-279S. (PMID: 16291123)
J Biomech. 2009 Feb 9;42(3):341-8. (PMID: 19136113)
Orthop Clin North Am. 2011 Oct;42(4):487-99, vii. (PMID: 21944586)
J Orthop Res. 2009 May;27(5):620-6. (PMID: 18991343)
J Surg Res. 2013 May;181(2):e65-74. (PMID: 22878152)
Eur Spine J. 2000 Jun;9(3):250-5. (PMID: 10905445)
Spine (Phila Pa 1976). 1998 Dec 1;23(23):2493-506. (PMID: 9854748)
Spine (Phila Pa 1976). 2002 Dec 1;27(23 ):2684-90. (PMID: 12461394)
Spine (Phila Pa 1976). 2006 Aug 15;31(18):2151-61. (PMID: 16915105)
J Biomech. 2010 Jan 19;43(2):334-42. (PMID: 19909959)
Arthritis Res Ther. 2003;5(3):120-30. (PMID: 12723977)
Spine (Phila Pa 1976). 2008 Mar 15;33(6):588-96. (PMID: 18344851)
Biomed Res Int. 2014;2014:461724. (PMID: 25045680)
Eur Spine J. 2017 Jun;26(6):1610-1617. (PMID: 28070685)
Spine (Phila Pa 1976). 1991 Mar;16(3):331-5. (PMID: 2028305)
Iowa Orthop J. 2014;34:137-43. (PMID: 25328473)
Spine J. 2012 Jan;12(1):7-20. (PMID: 22023960)
J Orthop Res. 2016 Aug;34(8):1382-8. (PMID: 27105019)
Spine J. 2006 Nov-Dec;6(6):692-703. (PMID: 17088200)
J Bone Joint Surg Br. 1996 Nov;78(6):965-72. (PMID: 8951017)
Front Bioeng Biotechnol. 2015 Feb 11;3:5. (PMID: 25717471)
Arthritis Rheum. 1980 Mar;23(3):319-24. (PMID: 7362683)
J Orthop Res. 1997 Mar;15(2):318-22. (PMID: 9167638)
J Orthop Res. 2013 Jun;31(6):831-7. (PMID: 23483579)
J Spinal Disord Tech. 2015 Apr;28(3):E146-53. (PMID: 25370985)
Eur Spine J. 2011 Apr;20(4):563-71. (PMID: 20936308)
Spine (Phila Pa 1976). 2008 Jul 15;33(16):1731-8. (PMID: 18628705)
J Mech Behav Biomed Mater. 2013 Jan;17 :229-41. (PMID: 23127644)
J Orthop Res. 2013 May;31(5):703-9. (PMID: 23255234)
J Mater Sci Mater Med. 2001 Aug;12(8):689-92. (PMID: 15348239)

DPI 2016-79302-R Secretaría de Estado de Investigación, Desarrollo e Innovación; Grant FPU13/01070 Ministerio de Educación, Cultura y Deporte

Keywords: Animal model; Experimental; Finite element model; Intervertebral disc degeneration; Lumbar spine

Date Created: 20171025 Date Completed: 20180917 Latest Revision: 20181113

20250114

10.1007/s11517-017-1738-3

29063365