Prevalence, virulence factors and antifungal susceptibility of Candida spp. isolated from bloodstream infections in a tertiary care hospital in Brazil.

Publisher: Grosse Verlag Country of Publication: Germany NLM ID: 8805008 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0507 (Electronic) Linking ISSN: 09337407 NLM ISO Abbreviation: Mycoses Subsets: MEDLINE

Original Publication: Berlin : Grosse Verlag, [1988?-

Antifungal Agents/*pharmacology ; Candida/*classification ; Candidemia/*microbiology; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Brazil/epidemiology ; Candida/drug effects ; Candida/isolation & purification ; Candida/pathogenicity ; Candida glabrata/drug effects ; Candida glabrata/isolation & purification ; Candida glabrata/pathogenicity ; Candidemia/epidemiology ; Candidemia/mortality ; Child ; Child, Preschool ; Drug Resistance, Fungal ; Female ; Humans ; Incidence ; Infant ; Infant, Newborn ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Prevalence ; Tertiary Care Centers ; Virulence Factors ; Young Adult

Candida spp. are responsible for 80% of all systemic fungal infections and are associated with high mortality rates. This study characterised 79 bloodstream isolates of C. albicans, C. glabrata, C. orthopsilosis, C. parapsilosis and C. tropicalis from patients in a Brazilian hospital. The susceptibility to amphotericin B, caspofungin, fluconazole and voriconazole was determined; virulence factor production was assessed based on haemolysin, phospholipase and proteinase activities, and the patients' clinical characteristics were analysed. C. albicans was the predominant species (44%), followed by C. glabrata (19%), C. tropicalis (19%), C. parapsilosis (14%) and C. orthopsilosis (4%). The candidemia incidence was 1.52 per 1000 admissions, and the crude mortality rate was 52%. One C. albicans isolate was resistant to fluconazole and voriconazole. Moreover, 20.2%, 2.5% and 3.8% of the isolates exhibited dose-dependent susceptibility to fluconazole, voriconazole and caspofungin, respectively. In conclusion, although the C. glabrata incidence was higher than that usually described in Brazil, its increase was previously observed in studies conducted worldwide. Furthermore, the azole resistance of the C. albicans isolate could be due to previous exposure to these antifungals. These results highlight the importance of epidemiological studies and will facilitate an improved understanding of candidemia in the studied hospital.
(© 2017 Blackwell Verlag GmbH.)

Keywords: Candida spp.; antifungal susceptibility; candidemia; virulence factors

0 (Antifungal Agents)
0 (Virulence Factors)

Date Created: 20170924 Date Completed: 20180817 Latest Revision: 20220321

20250114

10.1111/myc.12695

28940753