Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Ferruginol exhibits anticancer effects in OVCAR‑3 human ovary cancer cells by inducing apoptosis, inhibition of cancer cell migration and G2/M phase cell cycle arrest.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • المؤلفون: Xiong WD;Xiong WD; Gong J; Gong J; Xing C; Xing C
  • المصدر:
    Molecular medicine reports [Mol Med Rep] 2017 Nov; Vol. 16 (5), pp. 7013-7017. Date of Electronic Publication: 2017 Sep 13.
  • نوع النشر :
    Journal Article; Retracted Publication
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-3004 (Electronic) Linking ISSN: 17912997 NLM ISO Abbreviation: Mol Med Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Athens, Greece : D. A. Spandidos
    • الموضوع:
    • نبذة مختصرة :
      The primary aim of the current study was to investigate the antitumor effects of ferruginol in OVCAR‑3 human ovary cancer cells. The effects of ferruginol on cell apoptosis, cell migration and cell cycle phase distribution were also evaluated. Cell cytotoxicity induced by ferruginol was determined by an MTT assay, while fluorescence microscopy and transmission electron microscopy (TEM) were performed to investigate apoptotic effects. Flow cytometry was employed to determine the effects of ferruginol on the cell cycle and an in vitro wound healing assay was performed to investigate effects on cancer cell migration. The results indicated that ferruginol inhibited the growth rate of OVACR‑3 cells in a dose‑ and time‑dependent manner. When cells were treated with 20, 80 and 300 µM ferruginol, cells began to exhibit yellow fluorescence, which indicated the onset of apoptosis. TEM results demonstrated that untreated control cells exhibited intact nuclei and nucleolus. However, on treating cells with various doses of ferruginol, chromatin condensation occurred and disappearance of the nuclear envelope and formation of apoptotic bodies were also observed. The percentage of migrated cells, determined by the wound healing assay, decreased from 98.7% in control to 68.2% and 45.3 in 80 and 300 µM ferruginol‑treated cells, respectively. Flow cytometry results demonstrated that ferruginol induced G2/M cell cycle arrest in OVCAR‑3 cells. In conclusion, ferruginol may exhibit anticancer effects in OVCAR‑3 human ovary cancer cells by inducing apoptosis, inhibiting cancer cell migration and inducing G2/M cell and may therefore prove beneficial in the treatment and management of ovarian cancer.
    • Comments:
      Retraction in: Mol Med Rep. 2021 Apr;23(4):. (PMID: 33537814)
    • الرقم المعرف:
      0 (Abietanes)
      0 (Antineoplastic Agents, Phytogenic)
      0 (ferruginol)
    • الموضوع:
      Date Created: 20170914 Date Completed: 20180604 Latest Revision: 20220408
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.3892/mmr.2017.7484
    • الرقم المعرف:
      28901510