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Undetectable negative tissue transglutaminase IgA antibodies predict mucosal healing in treated coeliac disease patients.

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  • معلومة اضافية
    • المصدر:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8707234 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2036 (Electronic) Linking ISSN: 02692813 NLM ISO Abbreviation: Aliment Pharmacol Ther Subsets: MEDLINE
    • بيانات النشر:
      Publication: Oxford : Wiley-Blackwell
      Original Publication: [Oxford, OX] : Blackwell Scientific Publications, [c1987-
    • الموضوع:
      Diet, Gluten-Free*; Celiac Disease/*diagnosis ; GTP-Binding Proteins/*immunology ; Immunoglobulin A/*blood ; Transglutaminases/*immunology; Adult ; Aged ; Autoantibodies/blood ; Biopsy ; Female ; Humans ; Male ; Middle Aged ; Mucous Membrane ; Protein Glutamine gamma Glutamyltransferase 2 ; Retrospective Studies ; Wound Healing
    • نبذة مختصرة :
      Background: Tissue transglutaminase (tTG) immunoglobulin A (IgA) testing is a sensitive adjunct to the diagnosis of coeliac disease. The threshold for positivity was developed for diagnosis, with negative results reported as below the reference value (<4 U/mL).
      Aim: To investigate if an undetectable (tTG IgA<1.2 U/mL) is more predictive of healing compared to patients with negative but detectable serology (1.2-3.9 U/mL).
      Methods: We performed a retrospective study of 402 treated coeliac disease patients seen at the Mayo Clinic with negative tTG IgA values drawn within 1 month of duodenal biopsy between January 2009 and December 2015. The Corazza-Villanacci score was used to assess mucosal healing. The presence of gastrointestinal symptoms was also collected. Logistic regression was used to assess the relationship of clinical variables with a normal biopsy.
      Results: Patients with undetectable titres more frequently had normal duodenal histology compared to patients with detectable tTG IgA levels (117/240 vs. 53/162; OR=1.96; 1.292, 2.961). Asymptomatic patients more frequently had normal duodenum as compared to symptomatic patients (88/163 vs. 82/239; OR=2.25; CI: 1.494, 3.377). Patients with undetectable serology and on a gluten-free diet for ≥2 years were more likely to have no villous atrophy compared to patients with detectable serology (148/192 vs. 55/88; OR=2.02; CI: 1.17, 3.49).
      Conclusion: In subjects recovering from coeliac disease with negative tTG IgA serology, an undetectable titre is associated with normal histology on follow-up biopsy.
      (© 2017 John Wiley & Sons Ltd.)
    • Comments:
      Comment in: Aliment Pharmacol Ther. 2017 Nov;46(9):894-895. doi: 10.1111/apt.14287. (PMID: 29023879)
      Comment in: Aliment Pharmacol Ther. 2017 Nov;46(9):895-896. doi: 10.1111/apt.14333. (PMID: 29023882)
    • الرقم المعرف:
      0 (Autoantibodies)
      0 (Immunoglobulin A)
      EC 2.3.2.13 (Protein Glutamine gamma Glutamyltransferase 2)
      EC 2.3.2.13 (Transglutaminases)
      EC 3.6.1.- (GTP-Binding Proteins)
    • الموضوع:
      Date Created: 20170808 Date Completed: 20171214 Latest Revision: 20211204
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1111/apt.14250
    • الرقم المعرف:
      28782118