Cardiopulmonary Exercise Test in Leukemia Patients After Chemotherapy: A Feasibility Study.

Publisher: Korean Academy of Rehabilitation Medicine Country of Publication: Korea (South) NLM ID: 101573065 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2234-0645 (Print) Linking ISSN: 22340645 NLM ISO Abbreviation: Ann Rehabil Med Subsets: PubMed not MEDLINE

Original Publication: Korea : Korean Academy of Rehabilitation Medicine

Objective: To explore the feasibility of cardiopulmonary exercise test (CPET) in leukemia patients after chemotherapy.
Methods: Leukemia patients with histologically confirmed hematologic malignancies were reviewed. We evaluated for CPET, between receiving chemotherapy and undergoing stem cell transplantation after 2 weeks. We recorded exercise testing and physiologic parameters during CPET between January 2013 to May 2015. All patients were subjected to symptoms limited to exercise testing, according to the Modified Bruce Protocol. We considered that if respiratory exchange ratio achieved was over 1.10, participants had successfully completed CPET. We dichotomized all participants into two groups (normal group, normal range of resting heart rate; higher group, over 100 per minute of heart rate).
Results: 30 patients were finally enrolled. All participants had no adverse effects during the exercise test. Mean peak double product was 26,998.60 mmHg·beats/min (range, 15,481-41,004), and mean peak oxygen consumption (VO 2 peak) was 22.52±4.56 mL/kg/min. Significant differences were observed in the normal group with VO 2 peak (mean, 24.21 mL/kg/min; p=0.027) and number of prior intensive chemotherapy, compared to the higher group (mean, 1.95; p=0.006).
Conclusion: Our results indicate that CPET in leukemia patients before stem cell transplantation was very safe, and is an efficient method to screen for patients with poor cardiac functions. As CPET presents the parameters which reveal the cardiopulmonary functions, including VO 2 peak, double product and exercise capacity, this exercise test would help to predict the physical performance or general condition of the leukemia patients.
Competing Interests: CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported.

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Keywords: Exercise test; Feasibility studies; Leukemia; Rehabilitation; Tachycardia

Date Created: 20170801 Latest Revision: 20200930

20240829

PMC5532352

10.5535/arm.2017.41.3.456

28758084