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Protective effects of in vivo-expressed autotransporters against Bordetella pertussis infection.

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  • معلومة اضافية
    • المصدر:
      Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 7703966 Publication Model: Print Cited Medium: Internet ISSN: 1348-0421 (Electronic) Linking ISSN: 03855600 NLM ISO Abbreviation: Microbiol Immunol Subsets: MEDLINE
    • بيانات النشر:
      Publication: <2008- > : Richmond : Wiley-Blackwell
      Original Publication: 1977-<2007> : Tokyo : Center for Academic Publications Japan.
    • الموضوع:
      Antigens, Bacterial/*immunology ; Bordetella pertussis/*immunology ; Pertussis Vaccine/*immunology ; Type V Secretion Systems/*immunology ; Whooping Cough/*prevention & control; Animals ; Antibodies, Bacterial/immunology ; Antigenic Variation/immunology ; Bacterial Load/immunology ; Bacterial Proteins/immunology ; Female ; Mice ; Mice, Inbred BALB C ; Respiratory System/immunology ; Respiratory System/microbiology ; Serine Endopeptidases/immunology ; Vaccination ; Whooping Cough/immunology ; Whooping Cough/microbiology
    • نبذة مختصرة :
      Bordetella pertussis causes whooping cough, a severe and prolonged respiratory disease that results inhas high morbidity and mortality rates, particularly in developing countries. The number incidence of whooping cough cases is increasing in many countries despite high vaccine coverage. Causes for the re-emergence of the disease include the limited duration of protection conferred by the acellular pertussis vaccines (aP)s and pathogenic adaptations that involve antigenic divergence from vaccine strains. Therefore, current vaccines therefore need to be improved. In the present study, we focused on five autotransporters: namely SphB1, BatB, SphB2, Phg, and Vag8, which were previously found to be expressed by B. bronchiseptica during the course of infection in rats and examined their protective efficiencies as vaccine antigens. The passenger domains of these proteins were produced in recombinant forms and used as antigens. An intranasal murine challenge assay showed that immunization with a mixture of SphB1 and Vag8 (SV) significantly reduced bacterial load in the lower respiratory tract and a combination of aP and SV acts synergistically in effects of conferring protection against B. pertussis infection, implying that these antigens have potential as components to for improvinge th the currently available acellular pertussis vaccine.
      (© 2017 The Societies and John Wiley & Sons Australia, Ltd.)
    • Contributed Indexing:
      Keywords: Bordetella pertussis; autotransporter; protective antigen; vaccine
    • الرقم المعرف:
      0 (Antibodies, Bacterial)
      0 (Antigens, Bacterial)
      0 (Bacterial Proteins)
      0 (Pertussis Vaccine)
      0 (Type V Secretion Systems)
      EC 3.4.21.- (Serine Endopeptidases)
      EC 3.4.21.- (SphB1 protein, Bordetella pertussis)
    • الموضوع:
      Date Created: 20170729 Date Completed: 20180619 Latest Revision: 20180620
    • الموضوع:
      20221213
    • الرقم المعرف:
      10.1111/1348-0421.12504
    • الرقم المعرف:
      28752940