Evaluation of the phytochemical composition and protective activities of methanolic extracts of Centaurea borysthenica and Centaurea daghestanica (Lipsky) Wagenitz on cardiomyocytes treated with doxorubicin.

Publisher: Swedish Nutrition Foundation Country of Publication: Sweden NLM ID: 101488795 Publication Model: eCollection Cited Medium: Print ISSN: 1654-661X (Print) Linking ISSN: 1654661X NLM ISO Abbreviation: Food Nutr Res Subsets: PubMed not MEDLINE

Publication: 2018- : Lund : Swedish Nutrition Foundation
Original Publication: Bålsta : Co-Action Publishing

Centaurea L. is a genus of the family Asteraceae that comprises over 600 taxa. Representatives of the Centaurea genus were used as natural medications for many diseases. Methanolic-aqueous extracts from aerial parts of two Centaurea species: C. borysthenica Gruner and C. daghestanica (Lipsky) Wagenitz were studied for their polyphenolic composition and potential protective effect on cardiomyocytes treated with doxorubicin. Effectiveness of doxorubicin in cancer therapy is limited by a dose-dependent cardiotoxicity. Oxidative stress is a widely recognized mechanism of this phenomenon. One of the most important strategies has been an application of drug together with antioxidant agents. A cardioprotective effect of selected extracts of Centaurea species was suspected in this study. Cell viability, oxidative stress, and mitochondrial membrane potential analyses showed protective activity of the methanolic extract of C. borysthenica and C . daghestanica on rat cardiomyocytes treated with doxorubicin. Although C. borysthenica is more effective as a cardiomyocyte protective agent, in higher concentrations it weakened the drug activity. C. daghestanica extract did not change the doxorubicin efficacy in the evaluated experiment. Interestingly, both tested extracts were cytotoxic for myeloma cells. The detected antioxidant activity of the studied extracts can be used in the prevention of doxorubicin-induced cardiotoxicity.

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Keywords: Centaurea borysthenica Gruner; Centaurea daghestanica (Lipsky) Wagenitz; HPLC/PDA analysis; doxorubicin cardiotoxicity; flavonoids; oxidative stress; phenolic acids

Date Created: 20170728 Latest Revision: 20200930

20231215

PMC5510226

10.1080/16546628.2017.1344077

28747863