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Ventana immunohistochemistry assay for anaplastic lymphoma kinase gene rearrangement detection in patients with non-small cell lung cancer: A meta-analysis.

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  • معلومة اضافية
    • المصدر:
      Publisher: Wiley Publishing Asia Pty Ltd Country of Publication: Singapore NLM ID: 101531441 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-7714 (Electronic) Linking ISSN: 17597706 NLM ISO Abbreviation: Thorac Cancer Subsets: MEDLINE
    • بيانات النشر:
      Publication: November 2012- : Singapore : Tianjin : Wiley Publishing Asia Pty Ltd ; Tianjin Lung Cancer Institute
      Original Publication: Richmond, Vic. : Tianjin : Blackwell Pub. Asia Pty Ltd. ; Tianjin Lung Cancer Institute
    • الموضوع:
      Gene Rearrangement*; Carcinoma, Non-Small-Cell Lung/*metabolism ; Lung Neoplasms/*metabolism ; Receptor Protein-Tyrosine Kinases/*metabolism; Anaplastic Lymphoma Kinase ; Carcinoma, Non-Small-Cell Lung/genetics ; Humans ; Immunohistochemistry/methods ; Lung Neoplasms/genetics ; Oncogene Proteins, Fusion/metabolism ; ROC Curve ; Receptor Protein-Tyrosine Kinases/genetics ; Sensitivity and Specificity
    • نبذة مختصرة :
      Background: The aim of this study was to evaluate the diagnostic value of Ventana immunohistochemistry (IHC) assay for anaplastic lymphoma kinase (ALK) gene rearrangement screening in patients with non-small cell lung cancer (NSCLC).
      Methods: Open published studies that reported the diagnostic performance of Ventana IHC assay for ALK gene rearrangement detection in NSCLC patients were extracted from PubMed, Embase, Google scholar, Wanfang, and China National Knowledge Infrastructure. The general information and number of true positive (tp), false positive (fp), false negative (fn), and true negative (tn) cases identified by Ventana IHC assay were extracted. The diagnostic sensitivity, specificity, positive likelihood ratio (+lr), negative likelihood ratio (-lr), diagnostic odds ratio (dor) and the summary receiver operating characteristic (ROC) curve were calculated using Stata 11.0 software.
      Results: Ten studies, including 240 ALK positive and 1973 ALK negative NSCLC patients were included in this meta-analysis. The pooled diagnostic sensitivity, specificity, +lr, -lr, and dor were 0.94 (95% confidence interval [CI] 0.85-0.98), 1.00 (95% CI 0.99-1.00), 859.61 (95% CI 60.81-1200.00), 0.06 (95% CI 0.03-0.16), and 1400.00 (95% CI 813.29-23 000.00), respectively. The area under the ROC curve was 0.996 for Ventana IHC assay in detecting ALK gene rearrangement in NSCLC patients.
      Conclusion: The sensitivity and specificity of Ventana IHC assay for the detection of ALK gene rearrangement were high, thus Ventana IHC could substitute fluorescence in situ hybridization for the screening of ALK+ NSCLC patients.
      (© 2017 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.)
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    • Contributed Indexing:
      Keywords: Anaplastic lymphoma kinase gene; Ventana immunohistochemistry assay; meta-analysis; non-small cell lung cancer
    • الرقم المعرف:
      0 (Oncogene Proteins, Fusion)
      EC 2.7.10.1 (ALK protein, human)
      EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
      EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
    • الموضوع:
      Date Created: 20170726 Date Completed: 20180309 Latest Revision: 20181202
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC5582490
    • الرقم المعرف:
      10.1111/1759-7714.12468
    • الرقم المعرف:
      28742247