Effect of Oxidative Stress on Cardiovascular System in Response to Gravity.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Cardiovascular Physiological Phenomena*/radiation effects ; Gravitation* ; Oxidative Stress*/radiation effects; Animals ; Humans ; Radiation Exposure ; Reactive Oxygen Species ; Space Flight ; Weightlessness

Long-term habitation in space leads to physiological alterations such as bone loss, muscle atrophy, and cardiovascular deconditioning. Two predominant factors-namely space radiation and microgravity-have a crucial impact on oxidative stress in living organisms. Oxidative stress is also involved in the aging process, and plays important roles in the development of cardiovascular diseases including hypertension, left ventricular hypertrophy, and myocardial infarction. Here, we discuss the effects of space radiation, microgravity, and a combination of these two factors on oxidative stress. Future research may facilitate safer living in space by reducing the adverse effects of oxidative stress.
Competing Interests: The authors declare no conflict of interest.

Sci Rep. 2016 Jul 28;6:29901. (PMID: 27467019)
Antioxid Redox Signal. 2014 Mar 20;20(9):1501-23. (PMID: 24111926)
J Neurol. 2017 Mar 7;:null. (PMID: 28271409)
Radiat Res. 2004 Nov;162(5):572-9. (PMID: 15624312)
Life Sci Space Res (Amst). 2016 Aug;10 :53-6. (PMID: 27662788)
Curr Opin Clin Nutr Metab Care. 2003 Jan;6(1):31-40. (PMID: 12496678)
Dev Growth Differ. 2017 Jan;59(1):52-58. (PMID: 28093734)
Lancet Oncol. 2006 May;7(5):431-5. (PMID: 16648048)
PLoS One. 2012;7(8):e42224. (PMID: 22936983)
Biol Chem. 2002 Mar-Apr;383(3-4):715-21. (PMID: 12033461)
Redox Biol. 2017 Apr;11:482-501. (PMID: 28086196)
Eur J Appl Physiol. 2011 Mar;111(3):403-20. (PMID: 20617334)
Biophys Rep. 2016;2(5):100-105. (PMID: 28317013)
Nutrition. 2002 Oct;18(10):805-13. (PMID: 12361771)
Acta Astronaut. 2005 Jul-Oct;57(2-8):156-60. (PMID: 16010757)
J Appl Physiol (1985). 2009 Jun;106(6):1935-42. (PMID: 19342437)
Radiat Res. 2011 Oct;176(4):474-85. (PMID: 21787183)
Free Radic Res. 2014 Aug;48(8):890-7. (PMID: 24796731)
Nature. 2000 Nov 9;408(6809):239-47. (PMID: 11089981)
Bone. 2016 Jun;87:44-56. (PMID: 27032715)
Gerontology. 2010;56(2):157-66. (PMID: 19851058)
Vascul Pharmacol. 2006 Nov;45(5):268-76. (PMID: 17052961)
Cereb Cortex. 2002 Aug;12(8):883-91. (PMID: 12122037)
Annu Rev Physiol. 1972;34:205-34. (PMID: 4553491)
Nature. 2015 May 14;521(7551):217-221. (PMID: 25778702)
J Proteome Res. 2016 Jan 4;15(1):29-37. (PMID: 26523826)
J Appl Physiol (1985). 2009 Jan;106(1):251-8. (PMID: 18988766)
Chem Rev. 2016 Mar 9;116(5):3029-85. (PMID: 26875845)
Histol Histopathol. 2013 Mar;28(3):301-10. (PMID: 23348383)
Free Radic Biol Med. 2011 Sep 1;51(5):978-92. (PMID: 21627987)
Nature. 2016 Oct 06;538(7624):149-150. (PMID: 27734881)
PLoS One. 2014 Apr 23;9(4):e95916. (PMID: 24759683)
Radiat Res. 2016 Aug;186(2):153-61. (PMID: 27387862)
Aviat Space Environ Med. 1994 Jun;65(6):562-72. (PMID: 7915516)
Cell Commun Signal. 2013 Dec 20;11:98. (PMID: 24359439)
Free Radic Biol Med. 2007 Aug 1;43(3):332-47. (PMID: 17602948)
Free Radic Biol Med. 2011 Oct 1;51(7):1289-301. (PMID: 21777669)
Nat Rev Clin Oncol. 2013 Dec;10(12):697-710. (PMID: 24165948)
Antioxidants (Basel). 2017 May 13;6(2):null. (PMID: 28505091)
Radiat Res. 2013 Oct;180(4):340-50. (PMID: 24033191)
Free Radic Biol Med. 1998 Jan 15;24(2):385-90. (PMID: 9433915)
Free Radic Biol Med. 2003 Jul 1;35(1):9-16. (PMID: 12826251)
FASEB J. 2013 Nov;27(11):4466-75. (PMID: 23913861)
Curr Biol. 2013 Feb 4;23(3):R100-2. (PMID: 23391379)
Am J Physiol Endocrinol Metab. 2000 Mar;278(3):E375-82. (PMID: 10710490)
Eur J Appl Physiol. 2013 Sep;113(9):2171-81. (PMID: 23192310)
Health Phys. 2015 Feb;108(2):131-42. (PMID: 25551493)
World J Cardiol. 2015 Dec 26;7(12):882-8. (PMID: 26730293)
Sci Rep. 2015 Nov 24;5:17027. (PMID: 26596638)
Mutat Res. 2011 Jun 3;711(1-2):193-201. (PMID: 21216256)
PLoS One. 2012;7(3):e32361. (PMID: 22412864)
Arch Toxicol. 2008 May;82(5):273-99. (PMID: 18443763)
Radiat Res. 2013 Apr;179(4):444-57. (PMID: 23465079)
FEBS Lett. 2006 Jan 23;580(2):497-504. (PMID: 16386251)
Respir Physiol Neurobiol. 2009 Oct;169 Suppl 1:S10-2. (PMID: 19379845)
PLoS One. 2017 Jan 11;12 (1):e0169314. (PMID: 28076365)
Biomarkers. 2006 Nov-Dec;11(6):562-73. (PMID: 17056475)
Cell Signal. 1999 Jan;11(1):1-14. (PMID: 10206339)
Radiat Res. 2016 Jun;185(6):647-57. (PMID: 27243749)
Pflugers Arch. 2000;441(2-3 Suppl):R8-14. (PMID: 11200986)
Nutrition. 2002 Oct;18(10):867-71. (PMID: 12361781)
Neurochem Int. 2009 Dec;55(7):710-6. (PMID: 19616052)
Adv Space Res. 1986;6(11):243-9. (PMID: 11537228)
Life Sci Space Res. 1964;2:287-98. (PMID: 11881647)
Neurochem Res. 2010 Sep;35(9):1445-54. (PMID: 20571914)
Biomed Environ Sci. 2015 Nov;28(11):799-807. (PMID: 26695358)
Radiat Prot Dosimetry. 2015 Jun;164(4):477-83. (PMID: 25979747)
J Hypertens. 2015 Jun;33(6):1128-36. (PMID: 25882860)
Pharmacol Ther. 2013 Dec;140(3):239-57. (PMID: 23859953)
Circ Res. 2015 Apr 10;116(8):1431-47. (PMID: 25858067)
Int J Biochem Cell Biol. 2007;39(1):44-84. (PMID: 16978905)
In Vitro Cell Dev Biol Anim. 2005 Mar-Apr;41(3-4):118-23. (PMID: 16029073)
Radiat Res. 2000 May;153(5 Pt 1):487-96. (PMID: 10790268)
Int J Occup Med Environ Health. 2015 ;28(5):793-802. (PMID: 26224491)
N Engl J Med. 2013 Mar 14;368(11):987-98. (PMID: 23484825)

Keywords: microgravity; oxidative stress; radiation; reactive oxygen species

0 (Reactive Oxygen Species)

Date Created: 20170706 Date Completed: 20180326 Latest Revision: 20181113

20250114

PMC5535917

10.3390/ijms18071426

28677649