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Physical exercise intervention at school improved hepcidin, inflammation, and iron metabolism in overweight and obese children and adolescents.

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2012- : New York : Nature Publishing Group
      Original Publication: Basel ; New York : Karger.
    • الموضوع:
      Exercise* ; Health Promotion* ; Healthy Lifestyle* ; Risk Reduction Behavior* ; School Health Services*; Hepcidins/*blood ; Inflammation Mediators/*blood ; Interleukin-6/*blood ; Iron/*blood ; Pediatric Obesity/*prevention & control; Adiposity ; Adolescent ; Age Factors ; Biomarkers/blood ; Body Mass Index ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Humans ; Iron Deficiencies ; Longitudinal Studies ; Male ; Pediatric Obesity/blood ; Pediatric Obesity/diagnosis ; Pediatric Obesity/physiopathology ; Portugal ; Risk Factors ; Time Factors ; Treatment Outcome ; Weight Loss
    • نبذة مختصرة :
      BackgroundObesity is often associated with iron deficiency in children and adolescents. We aimed to study the effect of an 8-month physical exercise (PE) intervention on hepcidin and other markers of inflammation and on iron status in overweight/obese children and adolescents.MethodsSeventy-three overweight/obese children and adolescents participated in the 8-month-long longitudinal study. They were divided into two groups according to their participation in an after-school PE program: the PE group (n=44) and the control group (n=29). Hepcidin, interleukin (IL)-6, C-reactive protein (CRP), iron, ferritin, transferrin, and soluble transferrin receptor (sTfR) were evaluated.ResultsAt baseline, IL-6 correlated positively with hepcidin and negatively with iron and transferrin saturation, suggesting that increasing adiposity associates with increasing IL-6 and hepcidin synthesis, reducing iron availability. After 8 months, the PE group showed a decrease in BMI z-score (P=0.003), body fat mass (P=0.012), CRP (P=0.002), IL-6 (P=0.048), ferritin (P=0.013), hepcidin (P=0.040), and sTfR (P=0.010), and an increase in iron concentration (P=0.002). Moreover, the PE group, when compared with the control group, showed lower weight (P=0.026), BMI (P=0.040), waist circumference (P=0.010), and waist-to-height ratio (P=0.046).ConclusionWe showed that an 8-month-long intervention at school allowed a reduction in BMI z-score and an improvement in inflammation, reducing hepcidin levels and the disturbances in iron status.
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    • الرقم المعرف:
      0 (Biomarkers)
      0 (HAMP protein, human)
      0 (Hepcidins)
      0 (IL6 protein, human)
      0 (Inflammation Mediators)
      0 (Interleukin-6)
      E1UOL152H7 (Iron)
    • الموضوع:
      Date Created: 20170613 Date Completed: 20180611 Latest Revision: 20211204
    • الموضوع:
      20221213
    • الرقم المعرف:
      10.1038/pr.2017.139
    • الرقم المعرف:
      28604755