Maternal Lifetime Stress and Prenatal Psychological Functioning and Decreased Placental Mitochondrial DNA Copy Number in the PRISM Study.

Publisher: Oxford University Press Country of Publication: United States NLM ID: 7910653 Publication Model: Print Cited Medium: Internet ISSN: 1476-6256 (Electronic) Linking ISSN: 00029262 NLM ISO Abbreviation: Am J Epidemiol Subsets: MEDLINE

Publication: Cary, NC : Oxford University Press
Original Publication: Baltimore, School of Hygiene and Public Health of Johns Hopkins Univ.

DNA Copy Number Variations* ; Placenta*; DNA, Mitochondrial/*blood ; Depression/*physiopathology ; Oxidative Stress/*physiology ; Pregnancy Complications/*psychology ; Stress Disorders, Post-Traumatic/*physiopathology ; Stress, Psychological/*physiopathology; Black or African American/psychology ; Black or African American/statistics & numerical data ; Biomarkers/blood ; DNA, Mitochondrial/genetics ; Depression/genetics ; Educational Status ; Female ; Hispanic or Latino/psychology ; Hispanic or Latino/statistics & numerical data ; Humans ; Infant, Newborn ; Linear Models ; Male ; Massachusetts/epidemiology ; Oxidative Stress/genetics ; Pregnancy ; Pregnancy Complications/ethnology ; Pregnancy Complications/etiology ; Pregnancy Complications/genetics ; Prospective Studies ; Stress Disorders, Post-Traumatic/genetics ; Stress, Psychological/genetics ; White People/psychology ; White People/statistics & numerical data

Psychosocial stress contributes to placental oxidative stress. Mitochondria are vulnerable to oxidative stress, which can lead to changes in mitochondrial DNA copy number (mtDNAcn). We examined associations of maternal lifetime stress, current negative life events, and depressive and posttraumatic-stress-disorder symptom scores with placental mtDNAcn in a racially/ethnically diverse sample (n = 147) from the Programming of Intergenerational Stress Mechanisms (PRISM) study (Massachusetts, March 2011 to August 2012). In linear regression analyses adjusted for maternal age, race/ethnicity, education, prenatal fine particulate matter exposure, prenatal smoking exposure, and the sex of the child, all measures of stress were associated with decreased placental mtDNAcn (all P values < 0.05). Weighted-quantile-sum (WQS) regression showed that higher lifetime stress and depressive symptoms accounted for most of the effect on mtDNAcn (WQS weights: 0.25 and 0.39, respectively). However, among white individuals, increased lifetime stress and posttraumatic stress disorder symptoms explained the majority of the effect (WQS weights: 0.20 and 0.62, respectively) while among nonwhite individuals, lifetime stress and depressive symptoms accounted for most of the effect (WQS weights: 0.27 and 0.55, respectively). These analyses are first to link increased maternal psychosocial stress with reduced placental mtDNAcn and add to literature documenting racial/ethnic differences in the psychological sequelae of chronic stress that may contribute to maternal-fetal health.
(© The Author(s) 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

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R01 HL095606 United States HL NHLBI NIH HHS; R01 HL114396 United States HL NHLBI NIH HHS; UL1 TR001433 United States TR NCATS NIH HHS; R01 ES013744 United States ES NIEHS NIH HHS; P30 ES006096 United States ES NIEHS NIH HHS; P30 ES023515 United States ES NIEHS NIH HHS; R00 ES024116 United States ES NIEHS NIH HHS; K99 ES024116 United States ES NIEHS NIH HHS

Keywords: PRISM cohort; biomarkers; maternal stress; mitochondrial abundance; mitochondrial function; oxidative stress; placenta; pregnancy

0 (Biomarkers)
0 (DNA, Mitochondrial)

Date Created: 20170609 Date Completed: 20171213 Latest Revision: 20240314

20240314

PMC5859981

10.1093/aje/kwx183

28595325