Outcomes of acute kidney injury in a department of internal medicine in ABIDJAN (cote D'IVOIRE).

Publisher: Blackwell Science Country of Publication: Australia NLM ID: 9615568 Publication Model: Print Cited Medium: Internet ISSN: 1440-1797 (Electronic) Linking ISSN: 13205358 NLM ISO Abbreviation: Nephrology (Carlton) Subsets: MEDLINE

Original Publication: Carlton, Vic., Australia : Blackwell Science,

Hospital Departments* ; Internal Medicine*; Acute Kidney Injury/*therapy; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/mortality ; Acute Kidney Injury/physiopathology ; Adult ; Cote d'Ivoire/epidemiology ; Female ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Patient Admission ; Prospective Studies ; Recovery of Function ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome

Aim: To investigate the prognostic factors of acute kidney injury (AKI) in our daily practice.
Methods: We analyzed the cohort of patients hospitalized for AKI in the period from January 2010 to December 2015 in the Department of Internal Medicine, University Hospital of Treichville. Kaplan-Meier curves were built for survival analysis. Cox regression analysis was used to identify independent predictors of mortality.
Results: We collected 414 cases of AKI during the study period. The mean age was 48.3 ± 16.8 years. We observed a male predominance with a sex ratio (236/178) of 1.32. In multivariate analysis, the predictive factors of death were age ≥ 65 years (HR = 2.13; 95% CI = 1.28-3.55; P = 0.004), AKI stage 3 (HR = 1.69; 95%CI = 1.13-2.50; P = 0.009), haemoglobin <8 g/dL (HR = 2.91; 95% CI = 1.79-4.72; P = 0.0001), infection (HR = 1.85; 95% CI = 1.21-2.83; P = 0.004) and drug-induced AKI (HR = 3.23; 95% CI = 1.65-6.29; P = 0.001). Factors associated with incomplete recovery or non-recovery of renal function beyond 3 months were age ≥ 65 years (OR = 4.76; 95% CI = 1.85-12.50;P = 0.001), hypertension (OR = 2.17; 95% CI = 1.07-4.34; P = 0.03), haemoglobin <8 g/dL (OR = 6.66; 95% CI = 2.94-8.28; P < 0.001), AKI stage 3 (OR = 9.09; 95% CI = 4.54-16.66; P < 0.001) malignant hypertension (OR = 5; 95% CI = 1.67-7.27; P = 0.005) and cancer (OR = 4.69; 95% CI = 2.22-6.63; P = 0.001).
Conclusion: The aetiologies are dominated by infections. The fatality rate is high and its risk factors are advanced age, low haemoglobin level, severe AKI, infection and drug intake. Prevention is essential.
(© 2017 Asian Pacific Society of Nephrology.)

Keywords: acute renal failure; anaemia; end-stage kidney disease; epidemiology

Date Created: 20170427 Date Completed: 20181126 Latest Revision: 20181126

20221213

10.1111/nep.13064

28444694