The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel.

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المؤلفون: Guerreiro PS;Guerreiro PS; Corvacho E; Corvacho E; Costa JG; Costa JG; Costa JG; Saraiva N; Saraiva N; Fernandes AS; Fernandes AS; Fernandes AS; Castro M; Castro M; Miranda JP; Miranda JP; Oliveira NG; Oliveira NG
المصدر:
Chemical biology & drug design [Chem Biol Drug Des] 2017 Oct; Vol. 90 (4), pp. 561-571. Date of Electronic Publication: 2017 May 03.
نوع النشر :
Journal Article
اللغة:
English

معلومة اضافية
- المصدر:
  Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-0285 (Electronic) Linking ISSN: 17470277 NLM ISO Abbreviation: Chem Biol Drug Des Subsets: MEDLINE
- بيانات النشر:
  Original Publication: Oxford : Wiley-Blackwell, 2006-
- الموضوع:
  Antineoplastic Agents/*pharmacology ; Benzoquinones/*pharmacology ; Breast Neoplasms/*drug therapy ; Cell Movement/*drug effects ; DNA-(Apurinic or Apyrimidinic Site) Lyase/*antagonists & inhibitors ; Neoplasm Invasiveness/*prevention & control ; Propionates/*pharmacology ; Taxoids/*pharmacology; Breast/drug effects ; Breast/metabolism ; Breast/pathology ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA-(Apurinic or Apyrimidinic Site) Lyase/metabolism ; Docetaxel ; Female ; Humans ; Neoplasm Invasiveness/pathology ; Oxidation-Reduction/drug effects
- نبذة مختصرة :
  The human apurinic/apyrimidinic endonuclease 1 (APE1) is an ubiquitous multifunctional DNA repair enzyme and a redox signalling protein. Our work addressed the inhibition of APE1 redox function using E3330, as single agent or in combination with docetaxel (DTX), in human breast cancer MDA-MB-231 cells. E3330 decreased the colony formation of DTX-treated cells. In addition, E3330 alone significantly reduced the collective cell migration as assessed by the wound-healing assay, whereas the combined treatment decreased chemoinvasion. These results suggest that the inhibition of APE1 redox function might have therapeutic potential by modulating cell migration and invasion in metastatic breast cancer.
  (© 2017 John Wiley & Sons A/S.)
- Contributed Indexing:
  Keywords: E3330; apurinic/apyrimidinic endonuclease 1; breast cancer; cell migration and invasion; docetaxel
- الرقم المعرف:
  0 (Antineoplastic Agents)
  0 (Benzoquinones)
  0 (Propionates)
  0 (Taxoids)
  136164-66-4 (E 3330)
  15H5577CQD (Docetaxel)
  EC 4.2.99.18 (APEX1 protein, human)
  EC 4.2.99.18 (DNA-(Apurinic or Apyrimidinic Site) Lyase)
- الموضوع:
  Date Created: 20170318 Date Completed: 20170925 Latest Revision: 20181202
- الموضوع:
  20250114
- الرقم المعرف:
  10.1111/cbdd.12979
- الرقم المعرف:
  28303665

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The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel.

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