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Study of a novel disintegrable oleanolic acid-polyvinylpolypyrrolidone solid dispersion.

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  • المؤلفون: Wang W;Wang W; Cui C; Cui C; Li M; Li M; Zhang Z; Zhang Z; Zhang Z; Lv H; Lv H
  • المصدر:
    Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2017 Jul; Vol. 43 (7), pp. 1178-1185. Date of Electronic Publication: 2017 Mar 16.
  • نوع النشر :
    Journal Article
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 7802620 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5762 (Electronic) Linking ISSN: 03639045 NLM ISO Abbreviation: Drug Dev Ind Pharm Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: New York, Dekker.
    • الموضوع:
      Oleanolic Acid/*administration & dosage ; Povidone/*analogs & derivatives; Biological Availability ; Calorimetry, Differential Scanning ; Drug Stability ; Oleanolic Acid/chemistry ; Povidone/administration & dosage ; Povidone/chemistry ; Solubility
    • نبذة مختصرة :
      Novel solid dispersions of oleanolic acid-polyvinylpolypyrrolidone (OLA-PVPP SDs) were designed and prepared to improve the apparent solubility of drug, as well as to improve the stability, fluidity and compressibility of SDs. Disintegrable OLA-PVPP SDs were then evaluated both in vitro and in vivo. DSC, XRD, IR and SEM analysis proved the formation of OLA-PVPP SD and its amorphous state. The results of fluidity study, moisture absorption test and stability test showed that OLA-PVPP SD with good fluidity and qualified stability was successfully obtained. Meanwhile excellent dissolution rate was achieved for in vitro studies; dissolution test showed that ∼50-75% of OLA was dissolved from SDs within the first 10 min, which is about 10-15 times of free OLA. In vivo study indicated that the formation of solid dispersion could largely improve the absorption of OLA, resulting in a much shorter T max (p < .05) and higher C max (p < .01) than those of free drug. The AUC 0→∞ of OLA-PVPP SDs (1:6) were 155.4 ± 37.24 h·ng/mL compared to the 103.11 ± 26.69 h·ng/mL and 94.92 ± 13.05 h·ng/mL of OLA-PVPP physical mixture (1:6) and free OLA, respectively. These proved PVPP could be a promising carrier of solid dispersions and was industrially feasible alternative carrier in the manufacture of solid dispersions.
    • Contributed Indexing:
      Keywords: Solid dispersion; dissolution rate; oleanolic acid; polyvinylpolypyrrolidone; stability
    • الرقم المعرف:
      25249-54-1 (polyvinylpolypyrrolidone)
      6SMK8R7TGJ (Oleanolic Acid)
      FZ989GH94E (Povidone)
    • الموضوع:
      Date Created: 20170310 Date Completed: 20170913 Latest Revision: 20171116
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1080/03639045.2017.1301950
    • الرقم المعرف:
      28277846