Optogenetics: Applications in psychiatric research.

Publisher: Blackwell Science Country of Publication: Australia NLM ID: 9513551 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1819 (Electronic) Linking ISSN: 13231316 NLM ISO Abbreviation: Psychiatry Clin Neurosci Subsets: MEDLINE

Original Publication: Carlton, Vic., Australia : Blackwell Science,

Optogenetics/*methods ; Psychiatry/*methods; Animals ; Humans ; Neurosciences/methods ; Optogenetics/trends ; Psychiatry/trends

Recently, optogenetic techniques have emerged as a method to optically manipulate molecular and cellular events in target cells both in vitro and in vivo. Optogenetics results from the fruitful combination of optics and genetic engineering, maximizing the advantages of each discipline. These advantages are optical control through the manipulation of wavelength and light intensity on the millisecond timescale, and specific gene expression and gene product trafficking with subcellular precision. This kind of fine-tuning cannot be achieved using traditional methods. Therefore, optogenetic techniques have brought a revolution to neuroscience. In this review, we provide a concise summary of the history and recent advances of optogenetics, focusing in particular on applications for psychiatric research.
(© 2017 The Authors. Psychiatry and Clinical Neurosciences © 2017 Japanese Society of Psychiatry and Neurology.)

Keywords: action potential; circuit-centric therapeutics; neuronal network; opsins; optogenetics

Date Created: 20170225 Date Completed: 20180219 Latest Revision: 20180219

20231215

10.1111/pcn.12516

28233379