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Fast determination of codeine, orphenadrine, promethazine, scopolamine, tramadol, and paracetamol in pharmaceutical formulations by capillary electrophoresis.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101088554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-9314 (Electronic) Linking ISSN: 16159306 NLM ISO Abbreviation: J Sep Sci Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Weinheim, Germany : Wiley-VCH, c2001-
    • الموضوع:
      Electrophoresis, Capillary*; Acetaminophen/*analysis; Codeine/analysis ; Drug Compounding ; Orphenadrine/analysis ; Promethazine/analysis ; Scopolamine/analysis ; Tramadol/analysis
    • نبذة مختصرة :
      Paracetamol is an active ingredient commonly found in pharmaceutical formulations in combination with one of the following compounds: codeine, orphenadrine, promethazine, scopolamine, and tramadol. In this work, we propose a unique analytical method for determination of these active ingredients in pharmaceutical samples. The method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection. The separation was achieved on a fused silica capillary (50 cm total length, 40 cm effective length, and 50 μm id) using an optimized background electrolyte composed of 20 mmol/L β-alanine/4 mmol/L sodium chloride/4 μmol/L sodium hydroxide (pH 9.6). Each sample can be analyzed in a single run (≤2 min) and the limits of detection were 2.5, 0.62, 0.63, 2.5, 15, and 1.6 μmol/L for scopolamine, tramadol, orphenadrine, promethazine, codeine, and paracetamol, respectively. Recovery values for spiked samples were between 94 and 104%.
      (© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
    • Comments:
      Erratum in: J Sep Sci. 2021 Oct;44(19):3727. doi: 10.1002/jssc.202170194. (PMID: 34626086)
    • Contributed Indexing:
      Keywords: capillary electrophoresis; cations and anions; fast analysis; simultaneous analysis; waste prevention
    • الرقم المعرف:
      362O9ITL9D (Acetaminophen)
      39J1LGJ30J (Tramadol)
      AL805O9OG9 (Orphenadrine)
      DL48G20X8X (Scopolamine)
      FF28EJQ494 (Promethazine)
      UX6OWY2V7J (Codeine)
    • الموضوع:
      Date Created: 20170221 Date Completed: 20180618 Latest Revision: 20211009
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1002/jssc.201601275
    • الرقم المعرف:
      28217928