Anhedonia to music and mu-opioids: Evidence from the administration of naltrexone.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Anhedonia/*drug effects ; Anhedonia/*physiology ; Music/*psychology ; Naltrexone/*pharmacology ; Narcotic Antagonists/*pharmacology; Adult ; Cross-Over Studies ; Double-Blind Method ; Emotions/drug effects ; Emotions/physiology ; Female ; Humans ; Male

Music's universality and its ability to deeply affect emotions suggest an evolutionary origin. Previous investigators have found that naltrexone (NTX), a μ-opioid antagonist, may induce reversible anhedonia, attenuating both positive and negative emotions. The neurochemical basis of musical experience is not well-understood, and the NTX-induced anhedonia hypothesis has not been tested with music. Accordingly, we administered NTX or placebo on two different days in a double-blind crossover study, and assessed participants' responses to music using both psychophysiological (objective) and behavioral (subjective) measures. We found that both positive and negative emotions were attenuated. We conclude that endogenous opioids are critical to experiencing both positive and negative emotions in music, and that music uses the same reward pathways as food, drug and sexual pleasure. Our findings add to the growing body of evidence for the evolutionary biological substrates of music.
Competing Interests: The authors declare no competing financial interests.

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0 (Narcotic Antagonists)
5S6W795CQM (Naltrexone)

Date Created: 20170209 Date Completed: 20181026 Latest Revision: 20190109

20240829

PMC5296903

10.1038/srep41952

28176798