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The role of sex steroid hormones in benign prostatic hyperplasia.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 9808210 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-0790 (Electronic) Linking ISSN: 13685538 NLM ISO Abbreviation: Aging Male Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2015- : Abingdon, Oxford : Taylor & Francis
      Original Publication: New York : Parthenon Pub., c1998-
    • الموضوع:
      Androgens/*blood ; Estrogens/*blood ; Prostate-Specific Antigen/*blood ; Prostatic Hyperplasia/*etiology ; Testosterone/*blood; Age Distribution ; Aged ; Aged, 80 and over ; Androstenedione/blood ; Case-Control Studies ; Enzyme-Linked Immunosorbent Assay ; Humans ; Linear Models ; Lower Urinary Tract Symptoms/blood ; Lower Urinary Tract Symptoms/etiology ; Male ; Middle Aged ; Prostate ; Prostatic Hyperplasia/blood ; Prostatic Hyperplasia/complications ; Statistics, Nonparametric
    • نبذة مختصرة :
      Introduction: The etiology of benign prostatic hyperplasia (BPH) remains a mystery to scientists; estrogen/androgen imbalance in aged men has been implicated.
      Methods: Thirty (30) apparently healthy men and newly diagnosed BPH patients were recruited from the Ghana Police Hospital. Lower urinary tract syndrome (LUTS) and prostate volume were assessed via the prostate symptom score sheet (IPSS) and abdominopelvic scan, respectively. Laboratory assays for total prostate specific antigen (tPSA) and hormones [androstenedione (AED), testosterone (T), dihydrotestosterone (DHT), androstanedioladiol (3α-adiol), androstanediol (3β-diol), estrone (E1) and estradiol (E2)] were performed via ELISA techniques. Non-parametric analyses were employed. p < 0.05 was considered significant.
      Results: AED was significantly higher in controls compared to the BPH patients. AKRIC2 (3α-diol/DHT) was significantly higher in the BPH group (p < 0.001) whiles AKRIC1 (3β-diol/DHT) was significantly lower. Estradiol was significantly higher in BPH (p= 0.029). Age correlated negatively with T, while a negative correlation was observed between TIPSS and 3β-diol and AKRIC1. Also, prostate volume correlated negatively with fT.tPSA correlated positively with E2 and aromatase activity (E2/T) and negatively with fT. On multiple linear regression, DHT and 3β-diol remained independent predictors for TIPSS and fT for tPSA.
      Conclusion: Estrogens and androstanediols seem to play a role in BPH development.
    • Contributed Indexing:
      Keywords: Prostate; androgens; estrogen
    • الرقم المعرف:
      0 (Androgens)
      0 (Estrogens)
      3XMK78S47O (Testosterone)
      409J2J96VR (Androstenedione)
      EC 3.4.21.77 (Prostate-Specific Antigen)
    • الموضوع:
      Date Created: 20170114 Date Completed: 20170925 Latest Revision: 20170925
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1080/13685538.2016.1272101
    • الرقم المعرف:
      28084142