Acute pulmonary involvement by paracoccidiodomycosis disease immediately after kidney transplantation: Case report and literature review.

Publisher: Munksgaard Country of Publication: Denmark NLM ID: 100883688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-3062 (Electronic) Linking ISSN: 13982273 NLM ISO Abbreviation: Transpl Infect Dis Subsets: MEDLINE

Original Publication: Copenhagen : Munksgaard, c1999-

Antifungal Agents/*therapeutic use ; Graft Rejection/*therapy ; Immunosuppressive Agents/*therapeutic use ; Kidney Transplantation/*adverse effects ; Lung Diseases, Fungal/*diagnosis ; Paracoccidioides/*pathogenicity ; Paracoccidioidomycosis/*diagnosis; Amphotericin B/administration & dosage ; Amphotericin B/therapeutic use ; Antifungal Agents/administration & dosage ; Bronchoalveolar Lavage ; Bronchoalveolar Lavage Fluid/microbiology ; Bronchoscopy ; Female ; Graft Rejection/immunology ; Humans ; Imipenem/administration & dosage ; Imipenem/therapeutic use ; Immunity, Humoral ; Immunosuppression Therapy/methods ; Immunosuppressive Agents/administration & dosage ; Itraconazole/administration & dosage ; Kidney Failure, Chronic/surgery ; Latin America ; Lung Diseases, Fungal/complications ; Lung Diseases, Fungal/drug therapy ; Lung Diseases, Fungal/microbiology ; Methylprednisolone/administration & dosage ; Methylprednisolone/therapeutic use ; Middle Aged ; Paracoccidioides/isolation & purification ; Paracoccidioidomycosis/complications ; Paracoccidioidomycosis/drug therapy ; Paracoccidioidomycosis/microbiology ; Plasmapheresis ; Respiration, Artificial ; Tomography, X-Ray Computed ; Vancomycin/administration & dosage ; Vancomycin/therapeutic use

Paracoccidioides brasiliensis is the cause of paracoccidioidomycosis, one of the most important systemic mycoses in Latin America. Human disease has been observed in a limited geographic and ecological niche, and it is attributed to exposure to the fungus in soil. Most primary infections are subclinical, as the infection is contained by the host mainly through cell-mediated immune response. However, as the fungus has the ability to survive in a dormant state for long periods, an impairment of the immune response may lead to reactivation and clinical disease. Surprisingly, paracoccidioidomycosis has rarely been reported in transplanted patients. The aim of this communication is to report a case occurring in a kidney recipient in an acute clinical form immediately after transplantation, and to review the available information on previously reported cases.
(© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Keywords: endemic mycosis; kidney transplantation; liposomal amphotericin B; paracoccidioidomycosis; pulmonary disease

0 (Antifungal Agents)
0 (Immunosuppressive Agents)
0 (liposomal amphotericin B)
304NUG5GF4 (Itraconazole)
6Q205EH1VU (Vancomycin)
71OTZ9ZE0A (Imipenem)
7XU7A7DROE (Amphotericin B)
X4W7ZR7023 (Methylprednisolone)

Date Created: 20170101 Date Completed: 20170914 Latest Revision: 20211204

20231215

10.1111/tid.12655

28039947