Population-Based Study of Attitudes toward BRCA Genetic Testing among Orthodox Jewish Women.

Publisher: Wiley Country of Publication: United States NLM ID: 9505539 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4741 (Electronic) Linking ISSN: 1075122X NLM ISO Abbreviation: Breast J Subsets: MEDLINE

Publication: 2022- : [Hoboken, New Jersey] : [London] : Hindawi Wiley ;
Original Publication: Cambridge, MA : Blackwell Science, c1995-

Genetic Testing* ; Jews*/genetics ; Jews*/psychology; Genetic Predisposition to Disease/*psychology; Adult ; Aged ; Aged, 80 and over ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Cross-Sectional Studies ; Female ; Humans ; Logistic Models ; Middle Aged ; Mutation ; New York ; Ovarian Neoplasms/genetics ; Surveys and Questionnaires ; Young Adult

Given the high prevalence (1 in 40) of BRCA1 and BRCA2 mutations among Ashkenazi Jews, population-based BRCA genetic testing in this ethnic subgroup may detect more mutation carriers. We conducted a cross-sectional survey among Orthodox Jewish women in New York City to assess breast cancer risk, genetic testing knowledge, self-efficacy, perceived breast cancer risk and worry, religious and cultural factors affecting medical decision-making. We used descriptive statistics and multivariable logistic regression models to identify predictors of genetic testing intention/uptake. Among evaluable respondents (n = 243, 53% response rate), median age was 25 and nearly half (43%) had a family history of breast cancer. Only 49% of the women had adequate genetic testing knowledge and 46% had accurate breast cancer risk perceptions. Five percent had already undergone BRCA genetic testing, 20% stated that they probably/definitely will get tested, 28% stated that they probably/definitely will not get tested, and 46% had not thought about it. High decision self-efficacy, adequate genetic testing knowledge, higher breast cancer risk, and overestimation of risk were associated with genetic testing intention/uptake. Decision support tools that improve knowledge and self-efficacy about genetic testing may facilitate population-based BRCA testing among Orthodox Jews.
(© 2016 Wiley Periodicals, Inc.)

JAMA. 2004 Jul 28;292(4):442-52. (PMID: 15280342)
JAMA. 2001 Nov 14;286(18):2251-6. (PMID: 11710890)
Adv Genet. 2001;44:297-310. (PMID: 11596991)
Cancer Epidemiol Biomarkers Prev. 2000 Sep;9(9):973-5. (PMID: 11008917)
Stat Med. 2004 Apr 15;23(7):1111-30. (PMID: 15057881)
N Engl J Med. 1997 May 15;336(20):1401-8. (PMID: 9145676)
JAMA. 2005 Apr 13;293(14):1729-36. (PMID: 15827311)
JAMA. 1996 Jun 26;275(24):1885-92. (PMID: 8648868)
Med Decis Making. 2001 Jan-Feb;21(1):37-44. (PMID: 11206945)
Br J Soc Psychol. 2001 Dec;40(Pt 4):471-99. (PMID: 11795063)
J Clin Oncol. 2007 Apr 10;25(11):1329-33. (PMID: 17416853)
Ann Intern Med. 2014 Feb 18;160(4):271-81. (PMID: 24366376)
Clin Genet. 2000 May;57(5):376-83. (PMID: 10852372)
Fam Med. 2004 Sep;36(8):588-94. (PMID: 15343421)
JAMA. 2010 Sep 1;304(9):967-75. (PMID: 20810374)
J Natl Cancer Inst. 2014 Nov 30;107(1):379. (PMID: 25435541)
J Natl Cancer Inst. 2014 Nov 30;107(1):380. (PMID: 25435542)
J Clin Oncol. 2011 May 1;29(13):1664-9. (PMID: 21444874)

P30 CA013696 United States CA NCI NIH HHS; R01 CA177995 United States CA NCI NIH HHS; U01 HG008680 United States HG NHGRI NIH HHS; UL1 TR000040 United States TR NCATS NIH HHS

Keywords: BRCA1; BRCA2; Ashkenazi Jews; breast cancer risk; genetic testing

0 (BRCA1 Protein)
0 (BRCA1 protein, human)
0 (BRCA2 Protein)
0 (BRCA2 protein, human)

Date Created: 20161201 Date Completed: 20180307 Latest Revision: 20200609

20240628

PMC7278028

10.1111/tbj.12736

27900810