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Population-Based Study of Attitudes toward BRCA Genetic Testing among Orthodox Jewish Women.
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- معلومة اضافية
- المصدر:
Publisher: Wiley Country of Publication: United States NLM ID: 9505539 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4741 (Electronic) Linking ISSN: 1075122X NLM ISO Abbreviation: Breast J Subsets: MEDLINE
- بيانات النشر:
Publication: 2022- : [Hoboken, New Jersey] : [London] : Hindawi Wiley ;
Original Publication: Cambridge, MA : Blackwell Science, c1995-
- الموضوع:
- نبذة مختصرة :
Given the high prevalence (1 in 40) of BRCA1 and BRCA2 mutations among Ashkenazi Jews, population-based BRCA genetic testing in this ethnic subgroup may detect more mutation carriers. We conducted a cross-sectional survey among Orthodox Jewish women in New York City to assess breast cancer risk, genetic testing knowledge, self-efficacy, perceived breast cancer risk and worry, religious and cultural factors affecting medical decision-making. We used descriptive statistics and multivariable logistic regression models to identify predictors of genetic testing intention/uptake. Among evaluable respondents (n = 243, 53% response rate), median age was 25 and nearly half (43%) had a family history of breast cancer. Only 49% of the women had adequate genetic testing knowledge and 46% had accurate breast cancer risk perceptions. Five percent had already undergone BRCA genetic testing, 20% stated that they probably/definitely will get tested, 28% stated that they probably/definitely will not get tested, and 46% had not thought about it. High decision self-efficacy, adequate genetic testing knowledge, higher breast cancer risk, and overestimation of risk were associated with genetic testing intention/uptake. Decision support tools that improve knowledge and self-efficacy about genetic testing may facilitate population-based BRCA testing among Orthodox Jews.
(© 2016 Wiley Periodicals, Inc.)
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- Grant Information:
P30 CA013696 United States CA NCI NIH HHS; R01 CA177995 United States CA NCI NIH HHS; U01 HG008680 United States HG NHGRI NIH HHS; UL1 TR000040 United States TR NCATS NIH HHS
- Contributed Indexing:
Keywords: BRCA1; BRCA2; Ashkenazi Jews; breast cancer risk; genetic testing
- الرقم المعرف:
0 (BRCA1 Protein)
0 (BRCA1 protein, human)
0 (BRCA2 Protein)
0 (BRCA2 protein, human)
- الموضوع:
Date Created: 20161201 Date Completed: 20180307 Latest Revision: 20200609
- الموضوع:
20240628
- الرقم المعرف:
PMC7278028
- الرقم المعرف:
10.1111/tbj.12736
- الرقم المعرف:
27900810
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