Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Multimodal HPLC screening of polysaccharide-based chiral stationary phases.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • الموضوع:
      HIGH performance liquid chromatography; CHIRAL drugs; CHROMATOGRAPHIC analysis; ENANTIOMERS; JOHNSON & Johnson Pharmaceutical Research & Development LLC
    • نبذة مختصرة :
      High-performance liquid chromatography (HPLC) is a powerful tool for the enantioselective separation of chiral drugs. However, the selection of an appropriate chiral stationary phase (CSP) and suitable operating conditions is a bottleneck in method development and a time- and resource-consuming task. Multimodal screening of a small number of CSPs with broad enantiorecognition abilities has been recognized as the best strategy to achieve rapid and reliable separations of chiral compounds. This paper describes the generic screening strategy developed at Johnson & Johnson Pharmaceutical Research and Development to successfully develop enantioselective HPLC methods for chiral molecules of pharmaceutical interest. [ABSTRACT FROM AUTHOR]
    • نبذة مختصرة :
      Copyright of Pharmaceutical Technology Europe is the property of MJH Life Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)