Cardiovascular metabolic risk factors and glomerular filtration rate: a rural Chinese population study.

Publisher: BioMed Central Country of Publication: England NLM ID: 101147696 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-511X (Electronic) Linking ISSN: 1476511X NLM ISO Abbreviation: Lipids Health Dis Subsets: MEDLINE

Original Publication: [London] : BioMed Central, 2002-

Glomerular Filtration Rate* ; Waist Circumference*; Cardiovascular Diseases/*diagnosis ; Metabolic Syndrome/*diagnosis ; Renal Insufficiency, Chronic/*diagnosis; Adult ; Aged ; Aged, 80 and over ; Blood Glucose/metabolism ; Blood Pressure ; Body Weight ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/physiopathology ; China ; Cholesterol, HDL/blood ; Creatinine/blood ; Cross-Sectional Studies ; Fasting ; Female ; Humans ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/physiopathology ; Middle Aged ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/physiopathology ; Risk Factors ; Rural Population ; Triglycerides/blood

Methods: A total of 2426 study subjects from rural China aged 35 years and above (934 men and 1492 women) were enrolled in a cross-sectional survey. The eGFR calculation was based on the Modification of Diet in Renal Disease (MDRD) equation. The strength of the association between cardiovascular metabolic risk factors and eGFR was analyzed using a linear regression model.
Results: Cardiovascular metabolic risk factors, including age, body weight, waist circumference, fasting plasma glucose (FPG), creatinine (Cr), high-density lipoprotein-cholesterol (HDL-C), total cholesterol (TC), triglyceride (TG), systolic pressure, and diastolic pressure, were associated with eGFR. Additionally, the eGFR level gradually decreased and showed a linear trend with the increase in metabolic syndrome risk factors.
Conclusion: Metabolic risk factors are correlated with a reduction in renal function and CKD.

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Keywords: Cross-sectional survey; MetS; Rural Chinese population; eGFR

0 (Blood Glucose)
0 (Cholesterol, HDL)
0 (Triglycerides)
AYI8EX34EU (Creatinine)

Date Created: 20161014 Date Completed: 20170403 Latest Revision: 20181113

20250114

PMC5062868

10.1186/s12944-016-0346-9

27733200