Alterations in Factors Involved in Differentiation and Barrier Function in the Epithelium in Oral and Genital Lichen Planus.

Publisher: Society for the Publication of Acta Dermato-Venereologica Country of Publication: Sweden NLM ID: 0370310 Publication Model: Print Cited Medium: Internet ISSN: 1651-2057 (Electronic) Linking ISSN: 00015555 NLM ISO Abbreviation: Acta Derm Venereol Subsets: MEDLINE

Publication: 2006- : Uppsala: Society for the Publication of Acta Dermato-Venereologica
Original Publication: Stockholm : Acta dermato-venereologica

Cell Differentiation*; Epithelium/*physiopathology ; Genital Diseases, Female/*physiopathology ; Genital Diseases, Male/*physiopathology ; Lichen Planus, Oral/*physiopathology ; Mouth Mucosa/*physiopathology; 14-3-3 Proteins/analysis ; 14-3-3 Proteins/genetics ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Carrier Proteins/analysis ; Carrier Proteins/genetics ; Case-Control Studies ; Cytoskeletal Proteins ; Exoribonucleases/analysis ; Exoribonucleases/genetics ; Female ; Genital Diseases, Female/pathology ; Genital Diseases, Male/pathology ; Humans ; Inhibitor of Differentiation Proteins/analysis ; Inhibitor of Differentiation Proteins/genetics ; Intracellular Signaling Peptides and Proteins ; Lichen Planus, Oral/pathology ; Male ; Membrane Proteins/analysis ; Membrane Proteins/genetics ; Middle Aged ; Mouth Mucosa/chemistry ; Mouth Mucosa/pathology ; Neoplasm Proteins/analysis ; Neoplasm Proteins/genetics ; RNA, Messenger/analysis ; Receptors, Cell Surface/analysis ; Receptors, Cell Surface/genetics

Lichen planus is a chronic recurrent inflammatory disease affecting both skin and mucosa, mainly in oral and/or genital regions. Keratinocytes go through a well-regulated process of proliferation and differentiation, alterations in which may result in defects in the protective epithelial barrier. Long-term barrier impairment might lead to chronic inflammation. In order to broaden our understanding of the differentiation process in mucosal lichen planus, we mapped the expression of 4 factors known to be involved in differentiation. Biopsies were collected from oral and genital lichen planus lesions and normal controls. Altered expression of all 4 factors in epithelium from lichen planus lesions was found, clearly indicating disturbed epithelial differentiation in lichen planus lesions.

0 (14-3-3 Proteins)
0 (Biomarkers, Tumor)
0 (Carrier Proteins)
0 (Cytoskeletal Proteins)
0 (Inhibitor of Differentiation Proteins)
0 (Intracellular Signaling Peptides and Proteins)
0 (KAZN protein, human)
0 (Membrane Proteins)
0 (Neoplasm Proteins)
0 (RNA, Messenger)
0 (Receptors, Cell Surface)
0 (epithelial membrane protein-1)
147785-34-0 (ID3 protein, human)
EC 3.1.- (Exoribonucleases)
EC 3.1.- (SFN protein, human)

Date Created: 20160908 Date Completed: 20170228 Latest Revision: 20210122

20231215

10.2340/00015555-2533

27599552