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Molecular Models of STAT5A Tetramers Complexed to DNA Predict Relative Genome-Wide Frequencies of the Spacing between the Two Dimer Binding Motifs of the Tetramer Binding Sites.

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  • معلومة اضافية
    • المصدر:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: San Francisco, CA : Public Library of Science
    • الموضوع:
      DNA-Binding Proteins/*genetics ; STAT5 Transcription Factor/*genetics; Animals ; Binding Sites/genetics ; DNA-Binding Proteins/chemistry ; Humans ; Mice ; Models, Molecular ; STAT5 Transcription Factor/chemistry ; Tumor Suppressor Proteins/chemistry ; Tumor Suppressor Proteins/genetics
    • نبذة مختصرة :
      STAT proteins bind DNA as dimers and tetramers to control cellular development, differentiation, survival, and expansion. The tetramer binding sites are comprised of two dimer-binding sites repeated in tandem. The genome-wide distribution of the spacings between the dimer binding sites shows a distinctive, non-random pattern. Here, we report on estimating the feasibility of building possible molecular models of STAT5A tetramers bound to a DNA double helix with all possible spacings between the dimer binding sites. We found that the calculated feasibility estimates correlated well with the experimentally measured frequency of tetramer-binding sites. This suggests that the feasibility of forming the tetramer complex was a major factor in the evolution of this DNA sequence variation.
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    • Grant Information:
      P41 GM103311 United States GM NIGMS NIH HHS; P41 RR001081 United States RR NCRR NIH HHS
    • الرقم المعرف:
      0 (DNA-Binding Proteins)
      0 (STAT5 Transcription Factor)
      0 (STAT5A protein, human)
      0 (Stat5a protein, mouse)
      0 (Tumor Suppressor Proteins)
    • الموضوع:
      Date Created: 20160819 Date Completed: 20170724 Latest Revision: 20181113
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC4990345
    • الرقم المعرف:
      10.1371/journal.pone.0160339
    • الرقم المعرف:
      27537504