Liquid Biopsy of Hepatocellular Carcinoma: Circulating Tumor-Derived Biomarkers.

Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 8604127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8630 (Electronic) Linking ISSN: 02780240 NLM ISO Abbreviation: Dis Markers Subsets: MEDLINE

Publication: 2015- : New York, NY : Hindawi Pub. Corp.
Original Publication: Chichester ; New York : Wiley, c1983-

Biomarkers, Tumor/*blood ; Carcinoma, Hepatocellular/*blood ; Liver Neoplasms/*blood ; Neoplastic Cells, Circulating/*metabolism; Biopsy/methods ; Carcinoma, Hepatocellular/pathology ; DNA, Neoplasm/blood ; Humans ; Liver Neoplasms/pathology ; MicroRNAs/blood

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide due to latent liver disease, late diagnosis, and nonresponse to systemic treatments. Till now, surgical and/or biopsy specimens are still generally used as a gold standard by the clinicians for clinical decision-making. However, apart from their invasive characteristics, tumor biopsy only mirrors a single spot of the tumor, failing to reflect current cancer dynamics and progression. Therefore, it is imperative to develop new diagnostic strategies with significant effectiveness and reliability to monitor high-risk populations and detect HCC at an early stage. In the past decade, the potent utilities of "liquid biopsy" have attracted intense concern and were developed to evaluate cancer progression in several clinical trials. "Liquid biopsies" represent a series of noninvasive tests that detect cancer byproducts easily accessible in peripheral blood, mainly including circulating tumor cells (CTCs) and cell-free nucleic acids (cfNAs) that are shed into the blood from the tumor sites. In this review, we focus on the recent developments in the field of "liquid biopsy" as well as the diagnostic and prognostic significance of CTCs and cfNAs in HCC patients.

Cancer Epidemiol Biomarkers Prev. 1994 Jan-Feb;3(1):67-71. (PMID: 8118388)
Cancer Lett. 2008 Jun 18;264(2):201-8. (PMID: 18313840)
Nat Clin Pract Oncol. 2005 Dec;2 Suppl 1:S4-11. (PMID: 16341240)
Nat Med. 2011 Sep 07;17(9):1048-9. (PMID: 21900919)
Exp Mol Pathol. 2010 Feb;88(1):107-11. (PMID: 19818350)
Sci Transl Med. 2010 Mar 31;2(25):25ra23. (PMID: 20424012)
C R Seances Soc Biol Fil. 1948 Feb;142(3-4):241-3. (PMID: 18875018)
World J Gastroenterol. 2006 Jun 28;12(24):3911-4. (PMID: 16804981)
Clin Cancer Res. 2014 Sep 15;20(18):4794-805. (PMID: 25009297)
Clin Chem. 2008 Sep;54(9):1528-36. (PMID: 18653827)
Biomark Insights. 2013 Nov 14;8:127-36. (PMID: 24277982)
Hepatology. 2011 Oct;54(4):1227-36. (PMID: 21688285)
Dis Markers. 2013;34(3):163-9. (PMID: 23334650)
J Oncol. 2010;2010:617421. (PMID: 20016752)
Gastroenterology. 2011 Mar;140(3):1063-70. (PMID: 21094160)
Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1638-43. (PMID: 19366907)
Adv Drug Deliv Rev. 2015 Jan;81:75-93. (PMID: 25220354)
Oncotarget. 2015 Oct 20;6(32):32868-77. (PMID: 26451608)
Cell. 2007 Feb 23;128(4):683-92. (PMID: 17320506)
Nat Methods. 2013 Oct;10(10):1003-5. (PMID: 23995387)
Biochim Biophys Acta. 2007 Jan;1775(1):181-232. (PMID: 17137717)
Crit Rev Clin Lab Sci. 2014 Aug;51(4):200-31. (PMID: 24878357)
Cancer Res. 2010 Dec 1;70(23):9798-807. (PMID: 21098710)
Ann Transl Med. 2015 Mar;3(3):36. (PMID: 25815297)
Immunology. 2005 May;115(1):55-62. (PMID: 15819697)
BMJ Open. 2012 Mar 08;2(2):e000825. (PMID: 22403344)
Nat Rev Genet. 2002 Jun;3(6):415-28. (PMID: 12042769)
Curr Opin Biotechnol. 2008 Feb;19(1):36-40. (PMID: 18162393)
Clin Chem. 2013 Jan;59(1):211-24. (PMID: 23065472)
Clin Cancer Res. 2003 Mar;9(3):1047-52. (PMID: 12631605)
Clin Cancer Res. 2001 Aug;7(8):2222-7. (PMID: 11489795)
Cell. 2003 Jun 13;113(6):673-6. (PMID: 12809598)
Ann Surg Oncol. 2011 Aug;18(8):2182-91. (PMID: 21598056)
Nature. 2005 Jun 9;435(7043):834-8. (PMID: 15944708)
Gastroenterology. 2013 May;144(5):1031-1041.e10. (PMID: 23376424)
Nat Rev Cancer. 2010 Jan;10 (1):59-64. (PMID: 20029424)
Lancet. 2001 Apr 28;357(9265):1335-6. (PMID: 11343741)
Int J Med Sci. 2014 Jan 07;11(2):164-71. (PMID: 24465162)
Hepatology. 2008 Feb;47(2):503-10. (PMID: 18023026)
Hepatology. 2010 Mar;51(3):836-45. (PMID: 20041405)
PLoS One. 2011;6(12):e28486. (PMID: 22174818)
Nat Genet. 1999 Feb;21(2):163-7. (PMID: 9988266)
Cancer Res. 2000 Nov 1;60(21):5954-8. (PMID: 11085511)
Nat Rev Cancer. 2006 Sep;6(9):674-87. (PMID: 16929323)
Nature. 2006 Nov 23;444(7118):444-54. (PMID: 17122850)
Clin Cancer Res. 2007 Apr 15;13(8):2378-84. (PMID: 17438096)
Cancer. 1977 Aug;40(2):779-83. (PMID: 70268)
J Clin Gastroenterol. 2011 Apr;45(4):355-60. (PMID: 21278583)
ACS Appl Mater Interfaces. 2015 Nov 4;7(43):24001-7. (PMID: 26488449)
Clin Chim Acta. 2010 Apr 2;411(7-8):516-20. (PMID: 20064498)
Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1444-52. (PMID: 25791790)
Nucleic Acids Res. 2000 Apr 15;28(8):E32. (PMID: 10734209)
Br J Haematol. 1994 Apr;86(4):774-9. (PMID: 7918071)
Hepatology. 2011 Dec;54(6):2025-35. (PMID: 21837748)
Lancet. 2003 Dec 6;362(9399):1907-17. (PMID: 14667750)
Rev Assoc Med Bras (1992). 1995 Mar-Apr;41(2):91-3. (PMID: 8520603)
Oncogene. 2001 Mar 22;20(12):1509-18. (PMID: 11313894)
Hepatology. 2012 Nov;56(5):1631-40. (PMID: 22610915)
Carcinogenesis. 2005 Dec;26(12):2050-7. (PMID: 16000397)
Exp Mol Pathol. 2011 Dec;91(3):702-7. (PMID: 21884695)
Exp Mol Pathol. 2008 Oct;85(2):96-100. (PMID: 18691570)
World J Surg. 2004 Jul;28(7):721-6. (PMID: 15185002)
Nature. 2007 Dec 20;450(7173):1235-9. (PMID: 18097410)
Nucleic Acids Res. 2005 Sep 28;33(17):5394-403. (PMID: 16192569)
Biosci Trends. 2007 Aug;1(1):26-32. (PMID: 20103863)
Korean J Hepatol. 2004 Jun;10(2):88-98. (PMID: 15218342)
Cancer Res. 1998 May 15;58(10):2196-9. (PMID: 9605766)
Biochem Biophys Res Commun. 2011 Mar 4;406(1):70-3. (PMID: 21295551)
Future Oncol. 2013 Dec;9(12):1861-9. (PMID: 24295416)
Nat Biotechnol. 2008 Apr;26(4):462-9. (PMID: 18362881)
N Engl J Med. 2008 Jul 24;359(4):366-77. (PMID: 18596266)
Cancer Res. 1999 Jan 1;59(1):71-3. (PMID: 9892188)
J Cancer Res Clin Oncol. 2014 Jan;140(1):145-50. (PMID: 24281335)
Nucleic Acids Res. 2004 Jan 13;32(1):e10. (PMID: 14722226)
J Hepatol. 2012 Jan;56(1):167-75. (PMID: 21749846)
Pathol Oncol Res. 2012 Apr;18(2):271-6. (PMID: 21779787)
Hepatology. 2013 Apr;57(4):1458-68. (PMID: 23175471)
Best Pract Res Clin Gastroenterol. 2014 Oct;28(5):843-53. (PMID: 25260312)
BMC Cancer. 2014 Dec 10;14 :930. (PMID: 25496077)
Molecules. 2014 Feb 10;19(2):1912-38. (PMID: 24518808)
Clin Cancer Res. 2007 Feb 1;13(3):920-8. (PMID: 17289886)
Environ Health Perspect. 2011 Nov;119(11):1635-40. (PMID: 21768053)
Onco Targets Ther. 2014 Jul 18;7:1311-8. (PMID: 25071374)
Cancer Res. 2009 Jul 15;69(14):5776-83. (PMID: 19584273)
Biomarkers. 2009 Nov;14(7):529-38. (PMID: 19863192)
PLoS One. 2011;6(10):e26003. (PMID: 21998744)
Nat Rev Clin Oncol. 2014 Mar;11(3):129-44. (PMID: 24445517)
Int J Cancer. 2003 Feb 10;103(4):496-500. (PMID: 12478665)
Nature. 2009 Aug 27;460(7259):1127-31. (PMID: 19657334)
Int J Mol Sci. 2013 Sep 13;14(9):18925-58. (PMID: 24065096)
Mol Biol Rep. 2014 Jul;41(7):4513-9. (PMID: 24595450)
Science. 2010 Feb 26;327(5969):1074. (PMID: 20185705)
Cancer Lett. 2008 May 18;263(2):312-20. (PMID: 18280643)
CA Cancer J Clin. 2011 Jul-Aug;61(4):212-36. (PMID: 21685461)
Diagn Pathol. 2014 Jul 02;9:135. (PMID: 24993656)
Semin Oncol. 2012 Aug;39(4):440-8. (PMID: 22846861)
Nat Genet. 2003 Mar;33 Suppl:245-54. (PMID: 12610534)
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1317-25. (PMID: 25646427)
Clin Chem. 2006 Oct;52(10):1833-42. (PMID: 16423903)
Hepatology. 2004 Mar;39(3):792-7. (PMID: 14999698)
Cell Physiol Biochem. 2015;37(2):629-40. (PMID: 26344495)
Cancer Res. 1999 Jan 1;59(1):67-70. (PMID: 9892187)
Asian Pac J Cancer Prev. 2014;15(12):4969-76. (PMID: 24998573)
Clin Chem Lab Med. 2014 Aug;52(8):1235-45. (PMID: 24681432)
Nat Rev Cancer. 2004 Mar;4(3):177-83. (PMID: 14993899)
Hepatobiliary Pancreat Dis Int. 2013 Apr;12(2):171-9. (PMID: 23558072)

0 (Biomarkers, Tumor)
0 (DNA, Neoplasm)
0 (MicroRNAs)

Date Created: 20160713 Date Completed: 20170220 Latest Revision: 20220316

20221213

PMC4925990

10.1155/2016/1427849

27403030