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Liquid Biopsy of Hepatocellular Carcinoma: Circulating Tumor-Derived Biomarkers.
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- معلومة اضافية
- المصدر:
Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 8604127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8630 (Electronic) Linking ISSN: 02780240 NLM ISO Abbreviation: Dis Markers Subsets: MEDLINE
- بيانات النشر:
Publication: 2015- : New York, NY : Hindawi Pub. Corp.
Original Publication: Chichester ; New York : Wiley, c1983-
- الموضوع:
- نبذة مختصرة :
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide due to latent liver disease, late diagnosis, and nonresponse to systemic treatments. Till now, surgical and/or biopsy specimens are still generally used as a gold standard by the clinicians for clinical decision-making. However, apart from their invasive characteristics, tumor biopsy only mirrors a single spot of the tumor, failing to reflect current cancer dynamics and progression. Therefore, it is imperative to develop new diagnostic strategies with significant effectiveness and reliability to monitor high-risk populations and detect HCC at an early stage. In the past decade, the potent utilities of "liquid biopsy" have attracted intense concern and were developed to evaluate cancer progression in several clinical trials. "Liquid biopsies" represent a series of noninvasive tests that detect cancer byproducts easily accessible in peripheral blood, mainly including circulating tumor cells (CTCs) and cell-free nucleic acids (cfNAs) that are shed into the blood from the tumor sites. In this review, we focus on the recent developments in the field of "liquid biopsy" as well as the diagnostic and prognostic significance of CTCs and cfNAs in HCC patients.
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- الرقم المعرف:
0 (Biomarkers, Tumor)
0 (DNA, Neoplasm)
0 (MicroRNAs)
- الموضوع:
Date Created: 20160713 Date Completed: 20170220 Latest Revision: 20220316
- الموضوع:
20221213
- الرقم المعرف:
PMC4925990
- الرقم المعرف:
10.1155/2016/1427849
- الرقم المعرف:
27403030
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