A case-control analysis of smoking and breast cancer in African American women: findings from the AMBER Consortium.

Publisher: Irl Press At Oxford University Press Country of Publication: England NLM ID: 8008055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2180 (Electronic) Linking ISSN: 01433334 NLM ISO Abbreviation: Carcinogenesis Subsets: MEDLINE

Publication: Oxford : Irl Press At Oxford University Press
Original Publication: [New York, IRL Press]

Breast Neoplasms/*etiology ; Smoking/*adverse effects; Adult ; Black or African American/statistics & numerical data ; Aged ; Breast Neoplasms/epidemiology ; Case-Control Studies ; Female ; Humans ; Logistic Models ; Menopause ; Middle Aged ; Receptors, Estrogen/metabolism ; Smoking/epidemiology ; Triple Negative Breast Neoplasms/epidemiology ; Triple Negative Breast Neoplasms/etiology ; Young Adult

Recent population studies suggest a role of smoking in the etiology of breast cancer, but few have been conducted among African American women. In a collaborative project of four large studies, we examined associations between smoking measures and breast cancer risk by menopause and hormone receptor status [estrogen receptor-positive (ER+), ER-negative (ER-) and triple-negative (ER-, PR-, HER2-)]. The study included 5791 African American women with breast cancer and 17376 African American controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in multivariable logistic regression analysis with adjustment for study and risk factors. Results differed by menopausal status. Among postmenopausal women, positive associations were observed for long duration and greater pack-years of smoking: relative to never smoking, fully adjusted ORs were 1.14 (95% CI: 1.03-1.26) for duration ≥20 years and 1.16 (95% CI: 1.01-1.33) for ≥20 pack-years. By contrast, inverse associations were observed among premenopausal women, with ORs of 0.80 (95% CI: 0.68-95) for current smoking and 0.81 (95% CI: 0.69-0.96) for former smoking, without trends by duration. Associations among postmenopausal women were somewhat stronger for ER+ breast cancer. The findings suggest that the relation of cigarette smoking to breast cancer risk in African American women may vary by menopausal status and breast cancer subtype.
(© The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

Environ Mol Mutagen. 2002;39(2-3):119-26. (PMID: 11921179)
J Oncol. 2009;2009:871250. (PMID: 19865486)
Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):15-26. (PMID: 18187392)
Food Chem Toxicol. 2005 Jul;43(7):1017-27. (PMID: 15833377)
IARC Monogr Eval Carcinog Risks Hum. 2012;100(Pt E):1-538. (PMID: 23193840)
JAMA. 1996 Nov 13;276(18):1494-501. (PMID: 8903261)
J Natl Cancer Inst. 2011 Dec 21;103(24):1827-39. (PMID: 22158127)
J Natl Cancer Inst. 2013 Apr 17;105(8):515-25. (PMID: 23449445)
Cancer Causes Control. 2014 Mar;25(3):309-19. (PMID: 24343304)
Cancer Causes Control. 2013 Jul;24(7):1347-56. (PMID: 23633026)
Cancer. 2014 Apr 1;120(7):1026-34. (PMID: 24515648)
Steroids. 2011 Jun;76(7):653-9. (PMID: 21396948)
Breast J. 2014 Sep-Oct;20(5):468-80. (PMID: 25052559)
Breast Cancer Res Treat. 1995 Jul;35(1):51-60. (PMID: 7612904)
Eur J Endocrinol. 2005 Apr;152(4):491-9. (PMID: 15817903)
Br J Cancer. 2014 Apr 29;110(9):2339-47. (PMID: 24642621)
Br J Cancer. 2002 Nov 18;87(11):1234-45. (PMID: 12439712)
Cancer Epidemiol Biomarkers Prev. 2015 Mar;24(3):561-9. (PMID: 25542827)
Cancer Epidemiol Biomarkers Prev. 2013 Jul;22(7):1227-38. (PMID: 23825306)
Carcinogenesis. 2006 Jul;27(7):1377-85. (PMID: 16399771)
Lung Cancer. 2011 Dec;74(3):369-77. (PMID: 21620510)
Tob Control. 2015 Dec 14;:null. (PMID: 26666428)
Cancer Epidemiol. 2014 Aug;38(4):376-81. (PMID: 24929357)
Int J Cancer. 2015 May 1;136(9):2204-9. (PMID: 25307527)
Tob Control. 2011 Jan;20(1):e2. (PMID: 21148114)
IARC Monogr Eval Carcinog Risks Hum. 2004;83:1-1438. (PMID: 15285078)
Int J Cancer. 2014 Apr 15;134(8):1871-88. (PMID: 24590452)
Cancer Causes Control. 2013 Dec;24(12):2207-15. (PMID: 24085586)
Br J Cancer. 2011 Aug 23;105(5):709-22. (PMID: 21772329)
J Mammary Gland Biol Neoplasia. 2013 Mar;18(1):15-23. (PMID: 23179580)
Springerplus. 2014 Feb 03;3:65. (PMID: 24516791)
J Am Med Womens Assoc. 1995 Mar-Apr;50(2):56-8. (PMID: 7722208)
BMC Med Res Methodol. 2013;13:71. (PMID: 23721229)
N Engl J Med. 2006 Jan 26;354(4):333-42. (PMID: 16436765)
J Clin Endocrinol Metab. 2014 Apr;99(4):1384-92. (PMID: 24285681)
Menopause. 2004 Jan-Feb;11(1):104-9. (PMID: 14716190)
PLoS One. 2013;8(4):e63132. (PMID: 23646186)
JAMA. 1998 Jul 8;280(2):152-6. (PMID: 9669788)
Epidemiol Rev. 1993;15(1):145-56. (PMID: 8405197)
Am J Epidemiol. 2000 Feb 15;151(4):346-57. (PMID: 10695593)

P50 CA058223 United States CA NCI NIH HHS; UM1 CA164973 United States CA NCI NIH HHS; P30 CA016086 United States CA NCI NIH HHS; R01 CA058420 United States CA NCI NIH HHS; R01 CA100598 United States CA NCI NIH HHS; UM1 CA164974 United States CA NCI NIH HHS; P01 CA151135 United States CA NCI NIH HHS; P2C HD050924 United States HD NICHD NIH HHS

0 (Receptors, Estrogen)

Date Created: 20160522 Date Completed: 20170206 Latest Revision: 20221207

20231215

PMC4876991

10.1093/carcin/bgw040

27207658