Microbial translocation and skeletal muscle in young and old vervet monkeys.

Publisher: Springer Country of Publication: Netherlands NLM ID: 101250497 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1574-4647 (Electronic) Linking ISSN: 01619152 NLM ISO Abbreviation: Age (Dordr) Subsets: MEDLINE

Original Publication: Dordrecht, The Netherlands ; Hingham, MA : Springer, c2005-

Energy Metabolism*; Aging/*physiology ; Endotoxemia/*microbiology ; Intestinal Mucosa/*metabolism ; Motor Activity/*physiology ; Muscle, Skeletal/*physiopathology ; Sarcopenia/*physiopathology; Animals ; Bacterial Translocation ; Biomarkers/metabolism ; Chlorocebus aethiops ; Disease Models, Animal ; Endotoxemia/metabolism ; Female ; Insulin Resistance/physiology ; Intestines/microbiology ; Muscle, Skeletal/metabolism ; Sarcopenia/metabolism

Intestinal barrier dysfunction leads to microbial translocation (MT) and inflammation in vertebrate and invertebrate animal models. Age is recently recognized as a factor leading to MT, and in some human and animal model studies, MT was associated with physical function. We evaluated sarcopenia, inflammation, MT biomarkers, and muscle insulin sensitivity in healthy female vervet monkeys (6-27 years old). Monkeys were fed consistent diets and had large and varied environments to facilitate physical activity, and stable social conditions. Aging led to sarcopenia as indicated by reduced walking speeds and muscle mass, but general metabolic health was similar in older monkeys (n = 25) as compared to younger ones (n = 26). When older monkeys were physically active, their MT burden approximated that in young monkeys; however, when older monkeys were sedentary, MT burden was dramatically increased. MT levels were positively associated with inflammatory burden and negatively associated with skeletal muscle insulin sensitivity. Time spent being active was positively associated with insulin sensitivity as expected, but this relationship was specifically modified by the individual monkey's MT, not inflammatory burden. Our data supports clinical observations that MT interacts with physical function as a factor in healthy aging.
Competing Interests: Compliance with ethical standards All study procedures were approved by and performed in accordance with the Wake Forest University Institutional Animal Care and Use Committee.

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P40 OD010965 United States OD NIH HHS; T35 OD010946 United States OD NIH HHS; R21 AG049160 United States AG NIA NIH HHS; R21AG049160 United States AG NIA NIH HHS; P40OD010965 United States OD NIH HHS; UL1 TR001420 United States TR NCATS NIH HHS; T35OD010946 United States OD NIH HHS; R01 HL087103 United States HL NHLBI NIH HHS

Keywords: Endotoxemia; Insulin sensitivity; Intestinal barrier function; Non-human primate; Sarcopenia

0 (Biomarkers)

Date Created: 20160520 Date Completed: 20170112 Latest Revision: 20191210

20231215

PMC5005918

10.1007/s11357-016-9924-z

27194407