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Paracoccidioides brasiliensis PS2: First Autochthonous Paracoccidioidomycosis Case Report in Rio de Janeiro, Brazil, and Literature Review.
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- معلومة اضافية
- المصدر:
Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 7505689 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-0832 (Electronic) Linking ISSN: 0301486X NLM ISO Abbreviation: Mycopathologia Subsets: MEDLINE
- بيانات النشر:
Publication: Dordrecht : Kluwer Academic
Original Publication: [The Hague, W. Junk]
- الموضوع:
- نبذة مختصرة :
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by pathogenic dimorphic fungi of the Paracoccidioides brasiliensis complex. It is the most important systemic mycosis in Latin America, mainly in Brazil. Despite its severity and high mortality rates, it is considered a neglected disease. Species within the genus Paracoccidioides present genetics and morphological variations with probable clinical, diagnostic and therapeutic consequences. In fact, there are a very small number of detailed case reports with molecular identification of these fungal agents. Here, it is reported a case of PCM due to Paracoccidioides brasiliensis PS2. Molecular identification of the isolate was performed by amplification and sequencing of the arf and gp43 genes. Clinical cases and strain reports with molecular identification in the literature are also reviewed. The case herein presented is the first autochthonous report of PCM due to Paracoccidioides brasiliensis PS2 species in the state of Rio de Janeiro, Brazil, an important endemic area. The patient presented a chronic pulmonary form of PCM and had a satisfactory response to sulfamethoxazole/trimethoprim although sequelae such as adrenal insufficiency and dysphonia were observed. This study may contribute to improve the knowledge about this severe disease, its causative cryptic species and their consequences to patients.
- References:
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- Contributed Indexing:
Keywords: Molecular identification; Paracoccidioides brasiliensis PS2; Paracoccidioidomycosis; Pulmonary chronic disease
- الرقم المعرف:
0 (43 kDa protein, Paracoccidioides)
0 (Antigens, Fungal)
0 (Fungal Proteins)
0 (Glycoproteins)
EC 3.6.5.2 (ADP-Ribosylation Factors)
- الموضوع:
Date Created: 20160511 Date Completed: 20170403 Latest Revision: 20201209
- الموضوع:
20231215
- الرقم المعرف:
10.1007/s11046-016-0015-6
- الرقم المعرف:
27161127
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