Paracoccidioides brasiliensis PS2: First Autochthonous Paracoccidioidomycosis Case Report in Rio de Janeiro, Brazil, and Literature Review.

Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 7505689 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-0832 (Electronic) Linking ISSN: 0301486X NLM ISO Abbreviation: Mycopathologia Subsets: MEDLINE

Publication: Dordrecht : Kluwer Academic
Original Publication: [The Hague, W. Junk]

Lung Diseases, Fungal/*microbiology ; Lung Diseases, Fungal/*pathology ; Paracoccidioides/*isolation & purification ; Paracoccidioidomycosis/*microbiology ; Paracoccidioidomycosis/*pathology; ADP-Ribosylation Factors/genetics ; Adult ; Antigens, Fungal/genetics ; Brazil ; Cluster Analysis ; Fungal Proteins/genetics ; Glycoproteins/genetics ; Humans ; Lung Diseases, Fungal/diagnosis ; Male ; Paracoccidioides/classification ; Paracoccidioides/genetics ; Paracoccidioidomycosis/diagnosis ; Phylogeny ; Sequence Analysis, DNA ; Sequence Homology

Paracoccidioidomycosis (PCM) is a systemic mycosis caused by pathogenic dimorphic fungi of the Paracoccidioides brasiliensis complex. It is the most important systemic mycosis in Latin America, mainly in Brazil. Despite its severity and high mortality rates, it is considered a neglected disease. Species within the genus Paracoccidioides present genetics and morphological variations with probable clinical, diagnostic and therapeutic consequences. In fact, there are a very small number of detailed case reports with molecular identification of these fungal agents. Here, it is reported a case of PCM due to Paracoccidioides brasiliensis PS2. Molecular identification of the isolate was performed by amplification and sequencing of the arf and gp43 genes. Clinical cases and strain reports with molecular identification in the literature are also reviewed. The case herein presented is the first autochthonous report of PCM due to Paracoccidioides brasiliensis PS2 species in the state of Rio de Janeiro, Brazil, an important endemic area. The patient presented a chronic pulmonary form of PCM and had a satisfactory response to sulfamethoxazole/trimethoprim although sequelae such as adrenal insufficiency and dysphonia were observed. This study may contribute to improve the knowledge about this severe disease, its causative cryptic species and their consequences to patients.

J Clin Microbiol. 2001 Aug;39(8):2873-9. (PMID: 11474006)
Rev Inst Med Trop Sao Paulo. 2015 Sep;57 Suppl 19:31-7. (PMID: 26465367)
Fungal Genet Biol. 2008 May;45(5):605-12. (PMID: 18364259)
Fungal Genet Biol. 2008 Sep;45(9):1284-91. (PMID: 18672080)
Ann Clin Microbiol Antimicrob. 2010 Oct 12;9:30. (PMID: 20939907)
Am J Trop Med Hyg. 2014 Aug;91(2):394-8. (PMID: 24821845)
Fungal Genet Biol. 2011 Dec;48(12):1087-95. (PMID: 21945996)
J Clin Microbiol. 2013 Apr;51(4):1250-2. (PMID: 23345296)
Future Microbiol. 2013 Sep;8(9):1177-91. (PMID: 24020744)
Curr Opin Pulm Med. 1999 Sep;5(5):319-25. (PMID: 10461538)
Med Mycol. 2014 Jan;52(1):19-28. (PMID: 23768243)
Cad Saude Publica. 2002 Sep-Oct;18(5):1441-54. (PMID: 12244377)
PLoS One. 2012;7(10):e47033. (PMID: 23056569)
Rev Soc Bras Med Trop. 2011 Nov-Dec;44(6):777-80. (PMID: 22231254)
Med Mycol. 2012 Nov;50(8):843-51. (PMID: 22548242)
Mycoses. 2011 Jul;54(4):e122-9. (PMID: 20337937)
Med Mycol. 2016 Mar;54(3):240-7. (PMID: 26667263)
Mol Phylogenet Evol. 2009 Aug;52(2):273-83. (PMID: 19376249)
Med Mycol. 2006 May;44(3):219-25. (PMID: 16702100)
Mem Inst Oswaldo Cruz. 2013 Aug;108(5):637-43. (PMID: 23903981)
An Bras Dermatol. 2013 Sep-Oct;88(5):700-11. (PMID: 24173174)
PLoS Negl Trop Dis. 2016 Apr 07;10(4):e0004487. (PMID: 27054891)
Mycoses. 2014 Aug;57(8):466-72. (PMID: 24635832)
Biomedica. 2014 Jan-Mar;34(1):21-8. (PMID: 24967856)
BMC Microbiol. 2009 Dec 30;9:277. (PMID: 20042084)
Trop Med Int Health. 2015 May;20(5):673-680. (PMID: 25645820)
J Clin Microbiol. 2013 Feb;51(2):436-43. (PMID: 23175254)
Fungal Genet Biol. 2013 Nov;60:87-100. (PMID: 23911955)
PLoS Pathog. 2014 Oct 30;10(10):e1004397. (PMID: 25357210)
Mycoses. 2010 Mar 1;53(2):176-80. (PMID: 19422525)
BMC Genomics. 2010 Feb 23;11:130. (PMID: 20178623)
Mol Biol Evol. 2006 Jan;23(1):65-73. (PMID: 16151188)
Med Mycol. 2008 Feb;46(1):31-4. (PMID: 17885941)
Med Mycol. 2016 Feb;54(2):177-88. (PMID: 26384386)
J Clin Microbiol. 2006 Jun;44(6):2153-7. (PMID: 16757613)
Rev Soc Bras Med Trop. 2006 May-Jun;39(3):297-310. (PMID: 16906260)
PLoS One. 2012;7(5):e37694. (PMID: 22666382)
PLoS Negl Trop Dis. 2014 Sep 11;8(9):e3174. (PMID: 25211336)
Am J Trop Med Hyg. 2012 Oct;87(4):710-4. (PMID: 22927496)
Eukaryot Cell. 2013 Mar;12(3):380-9. (PMID: 23125354)
PLoS Negl Trop Dis. 2014 Dec 04;8(12):e3348. (PMID: 25474325)
Med Mycol. 2012 Oct;50(7):768-74. (PMID: 22493946)
Mycopathologia. 2013 Dec;176(5-6):345-52. (PMID: 24005606)
PLoS Genet. 2011 Oct;7(10):e1002345. (PMID: 22046142)

Keywords: Molecular identification; Paracoccidioides brasiliensis PS2; Paracoccidioidomycosis; Pulmonary chronic disease

0 (43 kDa protein, Paracoccidioides)
0 (Antigens, Fungal)
0 (Fungal Proteins)
0 (Glycoproteins)
EC 3.6.5.2 (ADP-Ribosylation Factors)

Date Created: 20160511 Date Completed: 20170403 Latest Revision: 20201209

20231215

10.1007/s11046-016-0015-6

27161127