Intraoperative Contrast Enhanced Ultrasound Evaluates the Grade of Glioma.

Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE

Original Publication: New York, NY : Hindawi Pub. Co.

Brain Neoplasms/*diagnostic imaging ; Brain Neoplasms/*pathology ; Glioma/*diagnostic imaging ; Glioma/*pathology ; Intraoperative Care/*methods ; Neoplasm Grading/*methods ; Ultrasonography/*methods; Adolescent ; Adult ; Aged ; Contrast Media ; Female ; Humans ; Image-Guided Biopsy/methods ; Male ; Middle Aged ; Young Adult

Objective: The aim of our study was to investigate the value of intraoperative contrast enhanced ultrasound (CEUS) for evaluating the grade of glioma and the correlation between microvessel density (MVD) and vascular endothelial growth factor (VEGF).
Methods: We performed intraoperative conventional ultrasound (CUS) and CEUS on 88 patients with gliomas. All of the patients have undergone surgery and obtained the results of pathology. All patients have undergone intraoperative CUS and CEUS to compare the characteristics of different grade gliomas and the results of CUS and CEUS were compared with pathological results.
Results: The time to start (TTS) and time to peak (TTP) of low grade glioma (LGG) were similar to those of edema and normal brain surrounding glioma. The enhanced extent of LGG was higher than that of the normal brain and edema. The TTS and TTP of high grade glioma were earlier than those of the edema and normal brain surrounding glioma. The enhancement of HGG was higher than that of LGG. The absolute peak intensity (API) was correlated with MVD and VEGF.
Conclusion: Intraoperative CEUS could help in determining boundary of peritumoral brain edema of glioma. Intraoperative CEUS parameters in cerebral gliomas could indirectly reflect the information of MVD and VEGF.

Comment in: Biomed Res Int. 2017;2017:3570895. (PMID: 28660208)
Erratum in: Biomed Res Int. 2017;2017:5782619. (PMID: 28808660)

Quant Imaging Med Surg. 2015 Apr;5(2):188-203. (PMID: 25853079)
J Neurosurg. 2005 Feb;102(2):295-301. (PMID: 15739558)
Biomed Res Int. 2014;2014:901642. (PMID: 24895624)
Radiologe. 2011 Jun;51(6):483-9. (PMID: 21584857)
Acta Neurochir (Wien). 2001;143(2):159-66. (PMID: 11459088)
Vet Radiol Ultrasound. 2013 May-Jun;54(3):283-92. (PMID: 23441645)
Genet Mol Res. 2015;14(2):3345-54. (PMID: 25966101)
Quant Imaging Med Surg. 2015 Apr;5(2):264-78. (PMID: 25853084)
Quant Imaging Med Surg. 2012 Jun;2(2):130-2. (PMID: 23256071)
Invest Radiol. 2011 Nov;46(11):686-96. (PMID: 21730873)
Neuroradiology. 2003 Apr;45(4):205-11. (PMID: 12687302)
Quant Imaging Med Surg. 2015 Apr;5(2):204-24. (PMID: 25853080)
Ultrasound Med Biol. 2013 Nov;39(11):2116-22. (PMID: 23993050)
J Neurosurg. 2001 Mar;94(3):464-73. (PMID: 11235952)
Acta Radiol. 2005 Nov;46(7):743-9. (PMID: 16372696)
Neurosurgery. 2014 May;74(5):542-52; discussion 552. (PMID: 24598809)
Biomed Res Int. 2014;2014:357258. (PMID: 25610862)
Biomed Res Int. 2014;2014:587806. (PMID: 24900973)
Clin Imaging. 2013 Nov-Dec;37(6):983-8. (PMID: 24035526)
Quant Imaging Med Surg. 2012 Jun;2(2):87-97. (PMID: 23061039)
Neurosurgery. 2007 Apr;60(4 Suppl 2):382-6; discussion 386-7. (PMID: 17415178)
Eur Radiol. 2011 Mar;21(3):604-15. (PMID: 20927527)
Int J Comput Assist Radiol Surg. 2015 May;10(5):531-40. (PMID: 24956998)
Annu Rev Pathol. 2006;1:97-117. (PMID: 18039109)
Chin Med J (Engl). 2015 Jan 20;128(2):186-90. (PMID: 25591560)
Quant Imaging Med Surg. 2012 Jun;2(2):68-80. (PMID: 22943043)
Stereotact Funct Neurosurg. 2000;75(2-3):147-52. (PMID: 11740184)
J Neurooncol. 2006 Aug;79(1):77-115. (PMID: 16607477)
Clin Cancer Res. 2003 Jun;9(6):1957-71. (PMID: 12796357)
Clin Imaging. 2008 Nov-Dec;32(6):419-24. (PMID: 19006768)

0 (Contrast Media)

Date Created: 20160413 Date Completed: 20161216 Latest Revision: 20181113

20240829

PMC4812195

10.1155/2016/2643862

27069921