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The unfolded protein response and programmed cell death are induced by expression of Garlic virus X p11 in Nicotiana benthamiana.

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  • معلومة اضافية
    • المصدر:
      Publisher: Microbiology Society Country of Publication: England NLM ID: 0077340 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1465-2099 (Electronic) Linking ISSN: 00221317 NLM ISO Abbreviation: J Gen Virol Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2015- : London : Microbiology Society
      Original Publication: London, Cambridge Univ. Press for the Society for General Microbiology.
    • الموضوع:
    • نبذة مختصرة :
      Garlic virus X (GarVX) ORF3 encodes a p11 protein, which contributes to virus cell-to-cell movement and forms granules on the endoplasmic reticulum (ER) in Nicotiana benthamiana. Expression of p11 either from a binary vector, PVX or TMV induced ER stress and the unfolded protein response (UPR), as demonstrated by an increase in transcription of the ER luminal binding protein (BiP) and bZIP60 genes. UPR-related programmed cell death (PCD) was elicited by PVX : p11 or TMV : p11 in systemic infected leaves. Examination of p11 mutants with deletions of two transmembrane domains (TM) revealed that both were required for generating granules and for inducing necrosis. TRV-based VIGS was used to investigate the correlation between bZIP60 expression and p11-induced UPR-related PCD. Less necrosis was observed on local and systemic leaves of bZIP60 knockdown plants when infected with PVXp11, suggesting that bZIP60 plays an important role in the UPR-related PCD response to p11 in N. benthamiana.
    • الرقم المعرف:
      0 (Plant Proteins)
      0 (Viral Proteins)
    • الموضوع:
      Date Created: 20160325 Date Completed: 20170428 Latest Revision: 20231213
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1099/jgv.0.000460
    • الرقم المعرف:
      27011387