Topical antifungal-corticosteroid combination therapy for the treatment of superficial mycoses: conclusions of an expert panel meeting.

Publisher: Grosse Verlag Country of Publication: Germany NLM ID: 8805008 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0507 (Electronic) Linking ISSN: 09337407 NLM ISO Abbreviation: Mycoses Subsets: MEDLINE

Original Publication: Berlin : Grosse Verlag, [1988?-

Adrenal Cortex Hormones/*administration & dosage ; Antifungal Agents/*administration & dosage ; Dermatomycoses/*drug therapy; Administration, Topical ; Adrenal Cortex Hormones/adverse effects ; Antifungal Agents/adverse effects ; Drug Therapy, Combination/adverse effects ; Expert Testimony ; Fluconazole/administration & dosage ; Fluconazole/adverse effects ; Humans ; Inflammation/drug therapy ; Patient Compliance

Superficial fungal infections affect 20-25% of people worldwide and can cause considerable morbidity, particularly if an inflammatory component is present. As superficial fungal infections can be diverse, the treatment should be tailored to the individual needs of the patient and several factors should be taken into account when deciding on the most appropriate treatment option. These include the type, location and surface area of the infection, patient age, degree of inflammation and underlying comorbidities. Although several meta-analyses have shown that there are no significant differences between the numerous available topical antifungal agents with regard to mycological cure, agents differ in their specific intrinsic properties, which can affect their clinical use. The addition of a corticosteroid to an antifungal agent at the initiation of treatment can attenuate the inflammatory symptoms of the infection and is thought to increase patient compliance, reduce the risk of bacterial superinfection and enhance the efficacy of the antifungal agent. However, incorrect use of antifungal-corticosteroid therapy may be associated with treatment failure and adverse effects. This review summarises available treatment options for superficial fungal infections and provides general treatment recommendations based on the consensus outcomes of an Expert Panel meeting on the topical treatment of superficial mycoses.
(© 2016 Blackwell Verlag GmbH.)

Keywords: Superficial fungal infection; antifungal; combination therapy; corticosteroid

0 (Adrenal Cortex Hormones)
0 (Antifungal Agents)
8VZV102JFY (Fluconazole)

Date Created: 20160227 Date Completed: 20170316 Latest Revision: 20170316

20240628

10.1111/myc.12481

26916648