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Neonatal phthalate ester exposure induced placental MTs, FATP1 and HFABP mRNA expression in two districts of southeast China.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Diethylhexyl Phthalate/*toxicity ; Fatty Acid Transport Proteins/*biosynthesis ; Fatty Acid-Binding Proteins/*biosynthesis ; Gene Expression Regulation/*drug effects ; Maternal Exposure/*adverse effects ; Metallothionein/*biosynthesis ; Placenta/*metabolism ; Pregnancy Proteins/*biosynthesis ; RNA, Messenger/*biosynthesis; Adult ; China ; Female ; Humans ; Infant, Newborn ; Male ; Pregnancy
    • نبذة مختصرة :
      Plastic production releases phthalate esters (PAEs), which can alter the expression of metallothioneins (MTs), fatty acid transport protein 1 (FATP1) and heart fatty acid binding protein (HFABP). A total of 187 mother-infant pairs were recruited, 127 from Chenghai (high exposed group) and 60 from Haojiang (low exposed group), to investigate the association between neonatal PAE exposure and mRNA expression of placental MTs, FATP1 and HFABP. Umbilical cord blood and placenta samples were collected for measuring five PAE concentrations and detecting mRNA levels of MTs, FATP1 and HFABP. Butylbenzyl phthalate (BBP), di(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP) were significantly higher in the high exposed group compared to the low exposed group. FATP1 and HFABP mRNA in the high exposed group were higher than that in the low exposed group while MT-1A was contrary. Both dimethyl phthalate (DMP) and DEHP were correlated with higher MT and MT-2A expression, while diethyl phthalate (DEP) was also positively correlated with MT-1A and FATP1 expression in female infants. DEHP exposure was negatively correlated with birth weight and gestational age in male infants. These results show that neonatal PAE exposure alters the mRNA expression of placental MTs and FATP1, which are related to fetal growth and development.
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    • الرقم المعرف:
      0 (Fatty Acid Transport Proteins)
      0 (Fatty Acid-Binding Proteins)
      0 (Pregnancy Proteins)
      0 (RNA, Messenger)
      0 (SLC27A1 protein, human)
      9038-94-2 (Metallothionein)
      C42K0PH13C (Diethylhexyl Phthalate)
    • الموضوع:
      Date Created: 20160213 Date Completed: 20161227 Latest Revision: 20181113
    • الموضوع:
      20240829
    • الرقم المعرف:
      PMC4751481
    • الرقم المعرف:
      10.1038/srep21004
    • الرقم المعرف:
      26867681