Age-dependent inverse correlations in CSF and plasma amyloid-β(1-42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Aging/*cerebrospinal fluid ; Alzheimer Disease/*blood ; Alzheimer Disease/*cerebrospinal fluid ; Amyloid beta-Peptides/*blood ; Amyloid beta-Peptides/*cerebrospinal fluid ; Brain/*metabolism ; Peptide Fragments/*blood ; Peptide Fragments/*cerebrospinal fluid ; Plaque, Amyloid/*blood ; Plaque, Amyloid/*cerebrospinal fluid; Aging/blood ; Animals ; Blood-Brain Barrier/metabolism ; Female ; Humans ; Immunohistochemistry ; Mice, Transgenic ; Phosphorylation ; Protein Transport

Amyloid-β (Aβ) plays a critical role as a biomarker in Alzheimer's disease (AD) diagnosis. In addition to its diagnostic potential in the brain, recent studies have suggested that changes of Aβ level in the plasma can possibly indicate AD onset. In this study, we found that plasma Aβ(1-42) concentration increases with age, while the concentration of Aβ(1-42) in the cerebrospinal fluid (CSF) decreases in APPswe, PS1M146V and TauP301L transgenic (3xTg-AD) mice, if measurements were made before formation of ThS-positive plaques in the brain. Our data suggests that there is an inverse correlations between the plasma and CSF Aβ(1-42) levels until plaques form in transgenic mice's brains and that the plasma Aβ concentration possesses the diagnostic potential as a biomarker for diagnosis of early AD stages.

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0 (Amyloid beta-Peptides)
0 (Peptide Fragments)
0 (amyloid beta-protein (1-42))

Date Created: 20160203 Date Completed: 20170106 Latest Revision: 20181113

20231215

PMC4735736

10.1038/srep20185

26830653