Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

A randomized controlled pilot study of inflammatory gene expression in response to a stress management intervention for stem cell transplant caregivers.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7807105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-3521 (Electronic) Linking ISSN: 01607715 NLM ISO Abbreviation: J Behav Med Subsets: MEDLINE
    • بيانات النشر:
      Publication: <2008->: New York, NY : Springer Science + Business Media
      Original Publication: New York, Plenum Press.
    • الموضوع:
      Cognitive Behavioral Therapy* ; Relaxation Therapy*/education; Caregivers/*psychology ; Gene Expression/*genetics ; Hematopoietic Stem Cell Transplantation/*psychology ; Inflammation Mediators/*blood ; Stress, Psychological/*genetics ; Stress, Psychological/*psychology; Adult ; Aged ; Caregivers/education ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Stress, Psychological/complications
    • نبذة مختصرة :
      Few studies have addressed whether stress-associated physiological changes in caregivers are reversible by psychological interventions mitigating distress. We report on pro-inflammatory, sympathetic, and oxidative stress gene expression in response to stress management for caregivers of allogeneic hematopoietic stem cell transplant (Allo-HSCT) patients. Following randomization by permuted block to either treatment as usual (TAU, n = 11) or a stress management intervention (PsychoEducation, Paced Respiration, and Relaxation, PEPRR, n = 13), twenty-four caregivers were selected at the conclusion of a larger trial of 149 caregivers. PEPRR was provided one-on-one beginning around transplant. Genome-wide transcriptional profiling was conducted on peripheral blood mononuclear cells collected prior to randomization and on completion of PEPRR 3 months post-transplant. Bioinformatics analysis of differentially expressed genes indicated reduced activity of transcription control pathways associated with inflammation (NF-κB), sympathetic nervous system (CREB), and oxidative stress (NRF2) in caregivers receiving PEPRR compared to TAU aligning with reductions in stress, depression, and anxiety. This suggests that PEPRR may alter transcriptomic effects reported for distressed individuals.
    • References:
      Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16574-9. (PMID: 24062448)
      J Health Soc Behav. 1983 Dec;24(4):385-96. (PMID: 6668417)
      Am J Med. 2006 Feb;119(2):166.e17-28. (PMID: 16443421)
      J Natl Cancer Inst Monogr. 2014 Nov;2014(50):295-301. (PMID: 25749595)
      Support Care Cancer. 2014 Dec;22(12):3331-40. (PMID: 25120010)
      Brain Behav Immun. 2013 Mar;30 Suppl:S10-8. (PMID: 23207104)
      Neuroimmunomodulation. 2008;15(4-6):251-9. (PMID: 19047802)
      N Engl J Med. 2006 Feb 16;354(7):719-30. (PMID: 16481639)
      Nephrol Nurs J. 2006 Mar-Apr;33(2):129. (PMID: 16613410)
      Neurosci Biobehav Rev. 2010 Sep;35(1):115-21. (PMID: 20026349)
      Ment Illn. 2014 Mar 25;6(1):5120. (PMID: 25478136)
      Psychoneuroendocrinology. 2014 May;43:20-9. (PMID: 24703167)
      Postgrad Med. 2011 Jan;123(1):114-9. (PMID: 21293091)
      Brain Behav Immun. 2014 Feb;36:1-8. (PMID: 24012646)
      Clin Psychol Sci. 2013 Jul;1(3):331-348. (PMID: 23853742)
      Biol Psychiatry. 2012 Feb 15;71(4):366-72. (PMID: 22088795)
      J Clin Oncol. 2012 Apr 10;30(11):1227-34. (PMID: 22412124)
      Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3080-5. (PMID: 21300872)
      Psychiatr Clin North Am. 2011 Sep;34(3):605-20. (PMID: 21889682)
      Psychooncology. 2013 Sep;22(9):2064-70. (PMID: 23440998)
      Dis Markers. 2011;30(2-3):123-32. (PMID: 21508516)
      Psychoneuroendocrinology. 2013 Mar;38(3):348-55. (PMID: 22795617)
      Brain Behav Immun. 2013 Mar;30 Suppl:S88-98. (PMID: 22627072)
      Lancet Oncol. 2013 Jul;14(8):721-32. (PMID: 23759376)
      Brain Behav Immun. 2012 Oct;26(7):1095-101. (PMID: 22820409)
      Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9090-5. (PMID: 12840146)
      Bioinformatics. 2005 Mar;21(6):803-10. (PMID: 15374858)
      Biol Psychiatry. 2008 Aug 15;64(4):266-72. (PMID: 18440494)
      Nat Rev Immunol. 2011 Aug 05;11(9):625-32. (PMID: 21818124)
      Psychosom Med. 2016 Feb-Mar;78(2):242-7. (PMID: 26569536)
      Bone Marrow Transplant. 2015 Aug;50(8):1110-8. (PMID: 25961767)
      Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5681-6. (PMID: 20176930)
      Curr Opin Support Palliat Care. 2014 Dec;8(4):391-3. (PMID: 25289929)
    • Grant Information:
      R01 CA126971 United States CA NCI NIH HHS; 1R01CA126971 United States CA NCI NIH HHS
    • Contributed Indexing:
      Keywords: Allogeneic hematopoietic stem cell transplant; Caregiver; Inflammatory pathways; Peripheral blood lymphocytes; Social genomics; Stress
    • الرقم المعرف:
      0 (Inflammation Mediators)
    • الموضوع:
      Date Created: 20160107 Date Completed: 20161213 Latest Revision: 20181202
    • الموضوع:
      20221213
    • الرقم المعرف:
      10.1007/s10865-015-9709-3
    • الرقم المعرف:
      26733011