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An essential cell cycle regulation gene causes hybrid inviability in Drosophila.

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  • معلومة اضافية
    • المصدر:
      Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
    • بيانات النشر:
      Publication: : Washington, DC : American Association for the Advancement of Science
      Original Publication: New York, N.Y. : [s.n.] 1880-
    • الموضوع:
      Genetic Speciation* ; Reproductive Isolation*; Carrier Proteins/*physiology ; Cell Cycle/*genetics ; Drosophila melanogaster/*genetics ; Drosophila simulans/*genetics ; Genes, Lethal/*physiology; Alleles ; Animals ; Carrier Proteins/genetics ; Chimera/genetics ; Crosses, Genetic ; Drosophila melanogaster/growth & development ; Drosophila simulans/growth & development ; Gene Expression Regulation, Developmental ; Genes, Essential/genetics ; Genes, Essential/physiology ; Genes, Insect ; Genes, Lethal/genetics ; Male ; Molecular Sequence Data
    • نبذة مختصرة :
      Speciation, the process by which new biological species arise, involves the evolution of reproductive barriers, such as hybrid sterility or inviability between populations. However, identifying hybrid incompatibility genes remains a key obstacle in understanding the molecular basis of reproductive isolation. We devised a genomic screen, which identified a cell cycle-regulation gene as the cause of male inviability in hybrids resulting from a cross between Drosophila melanogaster and D. simulans. Ablation of the D. simulans allele of this gene is sufficient to rescue the adult viability of hybrid males. This dominantly acting cell cycle regulator causes mitotic arrest and, thereby, inviability of male hybrid larvae. Our genomic method provides a facile means to accelerate the identification of hybrid incompatibility genes in other model and nonmodel systems.
      (Copyright © 2015, American Association for the Advancement of Science.)
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    • Grant Information:
      R01 GM115914 United States GM NIGMS NIH HHS; P30 CA015704 United States CA NCI NIH HHS; 5T32 HD0741 United States HD NICHD NIH HHS; HG006283 United States HG NHGRI NIH HHS; R01 GM074108 United States GM NIGMS NIH HHS; R01 HG006283 United States HG NHGRI NIH HHS; S10 OD020069 United States OD NIH HHS; United States HHMI_ Howard Hughes Medical Institute
    • Molecular Sequence:
      GENBANK KU064780; KU064781; KU064782; KU064783; KU064784; KU064785; KU064786; KU064787; KU064788; KU064789; KU064790; KU064791; KU064792; KU064793; KU064794; KU064795
    • الرقم المعرف:
      0 (Carrier Proteins)
      0 (GFZF protein, Drosophila)
    • الموضوع:
      Date Created: 20151219 Date Completed: 20160113 Latest Revision: 20220129
    • الموضوع:
      20240829
    • الرقم المعرف:
      PMC4703311
    • الرقم المعرف:
      10.1126/science.aac7504
    • الرقم المعرف:
      26680200