Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Effect of Bariatric Weight Loss on the Adipose Lipolytic Transcriptome in Obese Humans.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 9209001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1466-1861 (Electronic) Linking ISSN: 09629351 NLM ISO Abbreviation: Mediators Inflamm Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2005- : Sylvania, OH : Hindawi Pub. Corp.
      Original Publication: Oxford, UK : Rapid Communications of Oxford Ltd., c1992-
    • الموضوع:
      Bariatric Surgery* ; Lipolysis* ; Transcriptome*; Adipose Tissue/*metabolism ; Obesity/*surgery; Female ; Humans ; Lipase/genetics ; Male ; Obesity/metabolism ; Sterol Esterase/genetics ; Weight Loss
    • نبذة مختصرة :
      Background: Dysregulated lipolysis has been implicated in mechanisms of cardiometabolic disease and inflammation in obesity.
      Purpose: We sought to examine the effect of bariatric weight loss on adipose tissue lipolytic gene expression and their relationship to systemic metabolic parameters in obese subjects.
      Methods/results: We biopsied subcutaneous adipose tissue in 19 obese individuals (BMI 42 ± 5 kg/m(2), 79% female) at baseline and after a mean period of 8 ± 5 months (range 3-15 months) following bariatric surgery. We performed adipose tissue mRNA expression of proteins involved in triglyceride hydrolysis and correlated their weight loss induced alterations with systemic parameters associated with cardiovascular disease risk. mRNA transcripts of adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and lipid droplet proteins comparative gene identification 58 (CGI-58) and perilipin increased significantly after weight loss (p < 0.05 for all). ATGL expression correlated inversely with plasma triglyceride (TG), hemoglobin A1C (HbA1C), and glucose, and HSL expression correlated negatively with glucose, while CGI-58 was inversely associated with HbA1C.
      Conclusion: We observed increased expression of adipose tissue lipolytic genes following bariatric weight loss which correlated inversely with systemic markers of lipid and glucose metabolism. Functional alterations in lipolysis in human adipose tissue may play a role in shaping cardiometabolic phenotypes in human obesity.
    • References:
      Diabetes. 2005 Jun;54(6):1640-8. (PMID: 15919784)
      J Clin Invest. 2003 Dec;112(12):1821-30. (PMID: 14679177)
      Science. 2006 May 5;312(5774):734-7. (PMID: 16675698)
      Cell Metab. 2006 May;3(5):309-19. (PMID: 16679289)
      Int J Obes Relat Metab Disord. 2002 Jan;26(1):6-16. (PMID: 11791141)
      Circulation. 2002 Feb 5;105(5):564-9. (PMID: 11827920)
      J Clin Invest. 2006 Nov;116(11):3015-25. (PMID: 17053832)
      Physiol Rev. 2007 Apr;87(2):507-20. (PMID: 17429039)
      J Clin Invest. 2003 Dec;112(12):1796-808. (PMID: 14679176)
      Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1498-506. (PMID: 25908760)
      Am J Physiol. 1996 May;270(5 Pt 1):E739-45. (PMID: 8967459)
      Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1847-55. (PMID: 17327373)
      J Clin Endocrinol Metab. 2007 Jun;92(6):2292-9. (PMID: 17356053)
      Am J Physiol Endocrinol Metab. 2007 Oct;293(4):E958-64. (PMID: 17609260)
      Curr Diab Rep. 2009 Feb;9(1):26-32. (PMID: 19192421)
      Diabetes. 2009 Mar;58(3):718-25. (PMID: 19074987)
      Lancet. 2009 Mar 28;373(9669):1083-96. (PMID: 19299006)
      Diabetes. 2009 Apr;58(4):855-66. (PMID: 19136649)
      Biochim Biophys Acta. 2009 Jun;1791(6):494-500. (PMID: 19010445)
      J Physiol. 2009 Oct 15;587(Pt 20):4949-61. (PMID: 19723783)
      J Biol Chem. 2009 Oct 30;284(44):30218-29. (PMID: 19723629)
      J Biol Chem. 2009 Dec 11;284(50):34538-44. (PMID: 19850935)
      Diabetes Care. 2010 Nov;33(11):2297-303. (PMID: 20682679)
      J Clin Invest. 2011 May;121(5):1858-70. (PMID: 21490391)
      Metabolism. 2011 Jul;60(7):1012-20. (PMID: 21129760)
      J Am Coll Cardiol. 2011 Jul 12;58(3):232-7. (PMID: 21737012)
      J Clin Endocrinol Metab. 2011 Aug;96(8):E1293-7. (PMID: 21613358)
      JAMA. 2012 Jan 4;307(1):56-65. (PMID: 22215166)
      JAMA. 2012 Feb 1;307(5):491-7. (PMID: 22253363)
      Int J Obes (Lond). 2012 Feb;36(2):225-32. (PMID: 21556044)
      J Biol Chem. 2013 Apr 5;288(14):9892-904. (PMID: 23413028)
      J Am Coll Cardiol. 2013 Dec 17;62(24):2297-305. (PMID: 23978693)
      J Am Coll Cardiol. 2014 Jul 1;63(25 Pt B):2985-3023. (PMID: 24239920)
      N Engl J Med. 2014 Sep 18;371(12):1131-41. (PMID: 25229917)
      Circulation. 2014 Sep 23;130(13):1072-80. (PMID: 25116954)
      Sci Rep. 2015;5:7561. (PMID: 25557754)
      Br J Surg. 2015 May;102(6):682-90. (PMID: 25808987)
      Am J Clin Nutr. 2005 Dec;82(6):1178-84. (PMID: 16332649)
    • Grant Information:
      R01 HL114675 United States HL NHLBI NIH HHS; T32 HL007224 United States HL NHLBI NIH HHS; HL114675 United States HL NHLBI NIH HHS; HL081587 United States HL NHLBI NIH HHS; R01 HL126141 United States HL NHLBI NIH HHS; P01 HL081587 United States HL NHLBI NIH HHS; HL126141 United States HL NHLBI NIH HHS; T32 HL07224 United States HL NHLBI NIH HHS
    • الرقم المعرف:
      EC 3.1.1.13 (Sterol Esterase)
      EC 3.1.1.3 (Lipase)
    • الموضوع:
      Date Created: 20151215 Date Completed: 20160921 Latest Revision: 20220408
    • الموضوع:
      20231215
    • الرقم المعرف:
      PMC4667060
    • الرقم المعرف:
      10.1155/2015/106237
    • الرقم المعرف:
      26663986